Titre : | Obesity. Body mass index and mortality from ischaemic heart disease in a lean population : 10 year prospective study of 220000 adult men. (2006) |
Auteurs : | . ZHENGMING CHEN ; CHATURVEDI (Nish) / éd. : GBR. National Heart & Lung Institute. Imperial College at St Mary's. London. ; Rory COLLINS ; Shah EBRAHIM, éd. ; . GONGHUAN YANG ; . HONGCHAO PAN ; . JIEMING MA ; Debbie-A LAWLOR, éd. ; . LIJUN WANG ; . MAIGENG ZHOU ; Alison OFFER ; Richard PETO ; . SHIRU NIU ; Margaret Smith ; Gary WHITLOCK ; Chinese Academy of Medical Sciences. Institute of Basic Medical Sciences. Centre for Chronic Disease and Behaviour Risk Factors Surveillance. Beijing. CHN ; Chinese Center for Disease Control. Disease Surveillance Points. Beijing. CHN ; University of Oxford. Radcliffe Infirmary. Clinical Trial Service Unit & Epidemiological Studies Unit. (C.T.S.U.). GBR |
Type de document : | Article |
Dans : | International journal of epidemiology (vol. 35, n° 1, Janvier 2006) |
Pagination : | 141-150 |
Langues: | Anglais |
Mots-clés : | Facteur risque ; Epidémiologie ; Mortalité ; Chine ; Asie ; Anthropométrie ; Homme ; Appareil circulatoire [pathologie] ; Cardiopathie coronaire ; Myocarde [pathologie] ; Vaisseau sanguin [pathologie] |
Résumé : | [BDSP. Notice produite par INIST-CNRS DwUn9R0x. Diffusion soumise à autorisation]. Background : Increased body mass index (BMI) is known to be related to ischaemic heart disease (IHD) in populations where many are overweight (BMI>=2 5 kg/m2) or obese (BMI>=30). Substantial uncertainty remains, however, about the relationship between BMI and IHD in populations with lower BMI levels. Methods : We examined the data from a population-based, prospective cohort study of 222 000 Chinese men aged 40-79. Relative and absolute risks of death from IHD by baseline BMI were calculated, standardized for age, smoking, and other potential confounding factors. Results : The mean baseline BMI was 21.7 kg/m2, and 1942 IHD deaths were recorded during 10 years of follow-up (6.5% of all such deaths). Among men without prior vascular diseases at baseline, there was a J-shaped association between BMI and IHD mortality. Above 20 kg/m2 there was a positive association of BMI with risk, with each 2 kg/m2 higher in usual BMI associated with 12% (95% CI 6-19%, 2P=0.0001) higher IHD mortality. Below this BMI range, however, the association appeared to be reversed, with risk ratios of 1.00,1.09, and 1.15, respectively, for men with BMI 20-21.9,18-19.9, and |
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