Outbreak of Stevens-Johnson syndrome/toxic epiderm... Catalogue en ligne

Titre :	Outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with mebendazole and metronidazole use among Filipino laborers in Taiwan. (2003)
Auteurs :	Kow-Tong CHEN ; Hong-Jen CHANG ; Ruey-Shiung LIN ; Shiing-Jer TWU
Type de document :	Article
Dans :	American journal of public health (vol. 93, n° 3, 2003)
Pagination :	489-492
Langues:	Anglais
Mots-clés :	Vermifuge ; Facteur risque ; Complication ; Homme ; Composé nitré ; Peau [pathologie] ; Oeil [pathologie] ; Stomatologie
Résumé :	[BDSP. Notice produite par INIST-CNRS EHhR0xer. Diffusion soumise à autorisation]. Objectives. This study sought to identify the risk factors associated with an outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) among Filipino laborers in Taiwan. Methods. Forty-six SJS/TEN patients were matched to 92 controls according to month of arrival in Taiwan, sex, and age. Results. The odds ratio for development of SJS/TEN was 9.5 (95% confidence inter'val [Cl]=3.9,23.9) among workers who had used both metronidazole and mebendazole sometime in the preceding 6 weeks. In addition, a gradient increase in the occurrence of SJS/TEN was found with an increasing level of exposure to metronidazole. Conclusions. This outbreak highlights the risk of SJS/TEN resulting from the use of both metronidazole and mebendazole and the need for control measures.

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