Titre :
|
Outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with mebendazole and metronidazole use among Filipino laborers in Taiwan. (2003)
|
Auteurs :
|
Kow-Tong CHEN ;
Hong-Jen CHANG ;
Ruey-Shiung LIN ;
Shiing-Jer TWU
|
Type de document :
|
Article
|
Dans :
|
American journal of public health (vol. 93, n° 3, 2003)
|
Pagination :
|
489-492
|
Langues:
|
Anglais
|
Mots-clés :
|
Vermifuge
;
Facteur risque
;
Complication
;
Homme
;
Composé nitré
;
Peau [pathologie]
;
Oeil [pathologie]
;
Stomatologie
|
Résumé :
|
[BDSP. Notice produite par INIST-CNRS EHhR0xer. Diffusion soumise à autorisation]. Objectives. This study sought to identify the risk factors associated with an outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) among Filipino laborers in Taiwan. Methods. Forty-six SJS/TEN patients were matched to 92 controls according to month of arrival in Taiwan, sex, and age. Results. The odds ratio for development of SJS/TEN was 9.5 (95% confidence inter'val [Cl]=3.9,23.9) among workers who had used both metronidazole and mebendazole sometime in the preceding 6 weeks. In addition, a gradient increase in the occurrence of SJS/TEN was found with an increasing level of exposure to metronidazole. Conclusions. This outbreak highlights the risk of SJS/TEN resulting from the use of both metronidazole and mebendazole and the need for control measures.
|