| Titre : | Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. (2008) |
| Auteurs : | Eyal SHAHAR ; George-W COMSTOCK ; Aaron-R FOLSOM ; GENNARO (Valerio) : ITA. Environpmental Epidemiology Service. Istituto Nazionale per ln Ricerca sul Cancro. Genoa. ; Millicent-W HIGGINS ; KO (Wen-Jene) : USA. Collaborative Studies Coordinating Center. University of North Carolina. Chapel Hill. ; Sandra-L MELNICK ; Paul-D SORLIE ; Moyses Szklo ; Melvyn-S TOCKMAN ; Atherosclerosis Risk In Communities Study Investigators. INC ; Division of Epidemiology and Clinical Applications National Heart. Lung. And Blood Institute. Bethesda Md. USA ; Division of Epidemiology School of Public Health University of Minnesota. Minneapolis. USA ; Johm Hopkins School of Hygiene lid Public Health. Baltimore. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 168, n° 7, 2008) |
| Pagination : | 796-801 |
| Langues: | Anglais |
| Mots-clés : | Tabagisme ; Alimentation ; Aliment ; Régime alimentaire ; Tabac ; Epidémiologie ; Homme ; Lipide |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 8HnpR0xJ. Diffusion soumise à autorisation]. Background. Fish contain n-3 polyunsaturated fatty acids, principally eicosapentaenoic acid and docosahexaenoic add, which are known to interfere with the body's Inflammatory response and may be of benefit in chronic inflammatory conditions. Methods. We studied the relation between the dietary intake of n-3 fatty acids and chronic obstructive pulmonary disease (COPD) in 8960 current or former smokers participating in a population-based study of atherosclerosis. Intake of fatty acids was estimated with a dietary questionnaire. The presence of COPD was assessed by a questionnaire on respiratory symptoms and by spirometry. Three case definitions of COPD were used : symptoms of chronic bronchitis (667 subjects), physician-diagnosed emphysema reported by the subject (185 subjects), and spirometrically detected COPD (197 subjects). Results. After control for pack-years of smoking, age, sex, race, height, weight, energy intake, and educational level, the combined intake of eicosapentaenoic add and docosahexaenoic acid was inversely related to the risk of COPD in a quantity-dependent fashion. The adjusted odds ratio for the highest quartile of intake as compared with the lowest quartile was 0.66 for chronic bronchitis (95 percent confidence interval, 0.52 to 0.85 ; P<0.001 for linear trend across the range of intake values), 0.31 for physician-diagnosed emphysema (95 percent confidence interval, 0.18 to 0.52 ; P for linear trend, 0.003), and 0.50 for spirometrically detected COPD (95 percent confidence interval, 0.32 to 0.79 ; P for linear trend, 0.007). Conclusions. A high dietary intake of n-3 fatty acids may protect cigarette smokers against COPD. |
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