| Titre : | Vitamin D From Dietary Intake and Sunlight Exposure and the Risk of Hormone-Receptor-Defined Breast Cancer. (2008) |
| Auteurs : | Kristina-M BLACKMORE ; Heidi BARNETT ; Julia-A KNIGHT ; Maia LESOSKY ; RABOUD (Janet-M) : CAN. University Health Network. Toronto. ; VIETH (Reinhold) : CAN. Department of Pathology and Laboratory Medicine. Mount Sinai Hospital. Toronto. ; Prosserman Center for Health Research. Samuel Lunenfeld Research Institute. Mount Sinai Hospital. Toronto. CAN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 168, n° 8, 2008) |
| Pagination : | 915-924 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Vitamine D ; Alimentation ; Aliment ; Régime alimentaire ; Exposition ; Facteur risque ; Risque ; Sein ; Enquête cas témoin ; Epidémiologie ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS oB9sHR0x. Diffusion soumise à autorisation]. Evidence has emerged for a role of vitamin D in the development of breast cancer, and there is some suggestion that its antiproliferative effect is greater in hormone-receptor-positive cells. Few epidemiologic studies have considered the association between vitamin D and hormone-receptor-defined breast cancer, and the results are conflicting. Considering 759 cases and 1,135 controls from a case-control study (Ontario, Canada, 2003-2005), the authors examined the association between vitamin D intake at specific ages and combined estrogen-receptor- (ER) and progesterone-receptor- (PR) defined breast cancer. While increased intake of vitamin D (from the sun and diet) was most consistently associated with a significantly reduced risk of ER+/PR+tumors (e.g., odds ratio=0.76,95% confidence interval : 0.59,0.97 for use of cod liver oil during adolescence), comparable nonsignificant associations were found for receptor-negative (ER-/PR-) (odds ratio=0.74,95% confidence interval : 0.53,1.04) and mixed (ER+/PR-) (odds ratio=0.79,95% confidence interval : 0.51,1.22) tumors. This study suggests that vitamin D is associated with a reduced risk of breast cancer regardless of ER/PR status of the tumor. Future studies with a larger number of receptor-negative and mixed tumors are required. |
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