| Titre : | What Do Case-Control Studies Estimate ? Survey of Methods and Assumptions in Published Case-Control Research. (2008) |
| Auteurs : | KNOL (Mirjam-J) : NLD. Julius Center for Health Sciences and Primary Care. University Medical Center Utrecht. Utrecht. ; EGGER (Matthias) : GBR. Department of Social Medicine. University of Bristol. Bristol. ; Pippa SCOTT ; VANDENBROUCKE (Jan-P) : NLD. Department of Clinical Epidemiology. Leiden University Medical Center. Leiden. ; Institute of Social and Preventive Medicine. University of Bern. Bern. CHE |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 168, n° 9, 2008) |
| Pagination : | 1073-1081 |
| Langues: | Anglais |
| Mots-clés : | Enquête cas témoin ; Epidémiologie ; Estimation ; Enquête épidémiologique ; Enquête ; Surveillance ; Méthodologie ; Méthode ; Homme ; Risque relatif |
| Résumé : | [BDSP. Notice produite par INIST-CNRS r77R0xn8. Diffusion soumise à autorisation]. To evaluate strategies used to select cases and controls and how reported odds ratios are interpreted, the authors examined 150 case-control studies published in leading general medicine, epidemiology, and clinical specialist journals from 2001 to 2007. Most of the studies (125/150 ; 83%) were based on incident cases ; among these, the source population was mostly dynamic (102/125 ; 82%). A minority (23/125 ; 18%) sampled from a fixed cohort. Among studies with incident cases, 105 (84%) could interpret the odds ratio as a rate ratio. Fifty-seven (46% of 125) required the source population to be stable for such interpretation, while the remaining 48 (38% of 125) did not need any assumptions because of matching on time or concurrent sampling. Another 17 (14% of 125) studies with incident cases could interpret the odds ratio as a risk ratio, with 16 of them requiring the rare disease assumption for this interpretation. The rare disease assumption was discussed in 4 studies but was not relevant to any of them. No investigators mentioned the need for a stable population. The authors conclude that in current case-control research, a stable exposure distribution is much more frequently needed to interpret odds ratios than the rare disease assumption. At present, investigators conducting case-control studies rarely discuss what their odds ratios estimate. |
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