| Titre : | Prenatal exposure to 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene (p, p'-DDE) in relation to child growth : Intergenerational influences on health. (2006) |
| Auteurs : | RIBAS-FITO (Nuria) : ESP. Respiratory and Environmental Health Research Unit. Institut Municipal d'lnvestigacio Me'dica. Barcelona. ; BROCK (John-W) : USA. Department of Health and Human Services. National Center for Environmental Health. Centers for Disease Control and Prevention. ; Beth-C GLADEN ; KLEBANOFF (Mark-A) : USA. Department of Health and Human Services. National Institute of Child Health and Human Development. National Institutes of Health. ; Matthew-P LONGNECKER ; National Institutes of Health. National Institute of Environmental Health Sciences. Department of Health and Human Services. USA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 35, n° 4, 2006) |
| Pagination : | 853-861 |
| Langues: | Anglais |
| Mots-clés : | Exposition ; Enfant ; Homme ; Croissance ; Toxique ; Développement staturopondéral ; Etude prospective |
| Résumé : | [BDSP. Notice produite par INIST-CNRS cQR0x74v. Diffusion soumise à autorisation]. Objective : To examine the relation between prenatal 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene (p, p'-DDE) exposure (a metabolite of the insecticide DDT) and child growth during the first 7 years of life. Design : Prospective cohort study. Participants : 1712 children born between 1959 and 1966 with measured p. p'-DDE concentrations in their mother's serum samples from pregnancy. Setting : Multicenter US Collaborative Perinatal Project (CPP). Results : The highest prenatal concentrations of p, p'-DDE (>=60 mug/l), as compared with the lowest (<15 mug/l), were associated with decreased height at age 1 year [adjusted coefficient (SE)=-0.72 cm (0.37), n=1540], 4 years [-1.14 cm (0.56), n=1289], and 7 years [-2.19 (0.46), n=1371]. Among subjects in lower categories of exposure no association was observed. Conclusions : The findings suggest that high prenatal exposure to p, p'-DDE decreases height in children. Impaired growth may be a general indicator of toxicity and suggests that specific organ systems (e.g. endocrine) could be affected. |
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