| Titre : | Age at menarche, total mortality and mortality from ischaemic heart disease and stroke : the Adventist Health Study, 1976-88. (2009) |
| Auteurs : | JACOBSEN (B.K.) : NOR. Institute of Community Medicine. University of Tromso. Tromso. Tromso. ; FRASER (G.E.) : USA. Center for Health Research. School of Public Health. Loma Linda University. Loma Linda CA. ; S.F. KNUTSEN ; K. ODA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 38, n° 1, 2009) |
| Pagination : | 245-252 |
| Langues: | Anglais |
| Mots-clés : | Cardiopathie coronaire ; Accident cérébrovasculaire ; Age ; Mortalité ; Epidémiologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS l7R0x788. Diffusion soumise à autorisation]. Background : Little is known about the relationship between age at menarche and total mortality and mortality from ischaemic heart disease and stroke. Methods : A cohort study of 19462 Californian Seventh-Day Adventist women followed-up from 1976 to 1988. A total of 3313 deaths occurred during follow-up, of which 809 were due to ischaemic heart disease and 378 due to stroke. Results : An early menarche was associated with increased total mortality (P-value for linear trend<0.001), ischaemic heart disease (P-value for linear trend=0.01) and stroke (P-value for linear trend=0.02) mortality. There were, however, also some indications of an increased ischaemic heart disease mortality in women aged 16-18 at menarche (5% of the women). When assessed as a linear relationship, a 1-year delay in menarche was associated with 4.5% (95% CI 2.3-6.7) lower total mortality. The association was stronger for ischaemic heart disease [6.0% (95% CI 1.2-10.6) ] and stroke [8.6% (95% CI 1.6-15.1) ] mortality. Conclusions : The results suggest that there is a linear, inverse relationship between age at menarche and total mortality as well as with ischaemic heart disease and stroke mortality. |
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