| Titre : | Previous abortions and risk of pre-eclampsia. (2008) |
| Auteurs : | TROGSTAD (Lill) : NOR. Department of Obstetrics and Gynecology. Ullevaal University Hospital. Oslo. ; Per MAGNUS ; Rolv SKJAERVEN ; Camilla STOLTENBERG |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 37, n° 6, 2008) |
| Pagination : | 1333-1340 |
| Langues: | Anglais |
| Mots-clés : | IVG ; Facteur risque ; Risque ; Paternité ; Toxémie gravidique |
| Résumé : | [BDSP. Notice produite par INIST-CNRS qIqGnR0x. Diffusion soumise à autorisation]. Background : The risk of pre-eclampsia is reduced for second and later births. The causes and mechanisms behind this reduction are unknown. The aim of the study was to estimate the risk of pre-eclampsia in primiparous women according to history of spontaneous and induced abortions, while controlling for several potentially confounding factors. Methods : The sample consisted of 20 846 primiparous women participating in the Norwegian Mother and Child Cohort Study (MoBa). Information on abortions and confounders were self-reported in postal questionnaires. The diagnosis of pre-eclampsia was retrieved from the Medical Birth Registry of Norway. Estimation and confounder control was performed with multiple, logistic regression. Results : One previous induced abortion reduced the risk moderately [odds ratio (OR) 0.84,95% confidence interval (CI) 0.69-1.02]. Two or more induced abortions reduced the risk more significantly (OR 0.36,95% CI 0.18-0.73). Adjustment for confounders did not change the estimates. Conclusions : The protective effect of two prior induced abortions was similar to what is commonly seen after one birth. Spontaneous abortions may to a larger extent than induced abortions be associated with other factors, such as infertility, that may increase the risk of pre-eclampsia. Normal pregnancies interrupted in early pregnancy may induce immunological changes that reduce the risk of pre-eclampsia in a subsequent pregnancy. |
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