| Titre : | Circulating 25-Hydroxyvitamin D and Risk of Endometrial Cancer : Cohort Consortium Vitamin D Pooling Project of Rarer Cancers : Anticancer Vitamins du Jour : The ABCED's So Far. (2010) |
| Auteurs : | Anne ZELENIUCH-JACQUOTTE ; Alan-A ARSLAN ; Immaculata DE VIVO ; Lisa GALLICCHIO ; Yu-Tang GAO ; Susan-E HANKINSON ; Virginia HARTMULLER ; Richard-B HAYES ; Kathy-J HELZLSOUER ; Brian-E HENDERSON ; Ronald-L HORST ; . KAI YU ; Karen-L KOENIG ; Marjorie-L MCCULLOUGH ; Alpa-V PATEL ; Mark-P PURDUE ; Vwendy SETIAWAN ; Xiao-Ou SHU ; Kirk SNYDER ; Emily STEPLOWSKI ; . WEI ZHENG ; Stephanie-J WEINSTEIN ; Jocelyn-M Weiss ; Department of Environmental Medicine and Cancer Institute. School of Medicine. New York University. New York. NY. USA ; Department of Preventive Medicine. Norris Comprehensive Cancer Center. Keck School of Medicine. University of Southern California. Los Angeles. CA. USA ; Information Management Services Inc. Silver Spring. MD. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 172, n° 1, 2010) |
| Pagination : | 36-46 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Facteur risque ; Risque ; Vitamine D ; Enquête cas témoin ; Epidémiologie ; Endomètre ; Etude prospective |
| Résumé : | [BDSP. Notice produite par INIST-CNRS sIJsR0xq. Diffusion soumise à autorisation]. A nested case-control study, including 830 cases and 992 controls from 7 cohorts, was conducted to evaluate the association of circulating 25-hydroxyvitamin D (25 (OH) D), the best indicator of vitamin D status, with risk of endometrial cancer. Matching factors included age at blood donation, date of blood donation, and race. Conditional logistic regression was used in the main analysis. The median concentration of 25 (OH) D was slightly lower in cases (49.4 nmol/L) than in controls (50.8 nmol/L) (P=0.08). However, there was no association between 25 (OH) D concentration and disease risk, after adjustment for body mass index. Compared with the 50-<75 nmol/L 25 (OH) D category, the body mass index-adjusted odds ratios and 95% confidence intervals were 1.08 (95% confidence interval : 0.73,1.57) for the<25 nmol/L category and 0.90 (95% confidence interval : 0.51,1.58) for the>100 nmol/L category (Ptrend=0.99). Similarly null results were observed after further adjustment for other known risk factors and in stratified analyses. Although an effect of circulating 25 (OH) D at high concentrations cannot be ruled out (the highest category of 25 (OH) D was>=100 nmol/L, and for stratified analyses,>=75 nmol/L), these results do not support a protective role of vitamin D against endometrial cancer. |
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