| Titre : | Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer : Cohort Consortium Vitamin D Pooling Project of Rarer Cancers : Anticancer Vitamins du Jour : The ABCED's So Far. (2010) |
| Auteurs : | Christian-C ABNET ; Demetrius ALBANES ; Alan-A ARSLAN ; David-S CAMPBELL ; Peter-T CAMPBELL ; Wong-Ho CHOW ; Yu-Tang GAO ; Richard-B HAYES ; Kathy-J HELZLSOUER ; Ronald-L HORST ; . KAI YU ; Laurence-N KOLONEL ; Loic LE MARCHAND ; Marjorie-L MCCULLOUGH ; Abraham-My NOMURA ; Mark-P PURDUE ; James-M SHIKANY ; Xiao-Ou SHU ; Kirk SNYDER ; Jarmo VIRTAMO ; . WEI ZHENG ; Stephanie-J WEINSTEIN ; Yong-Bing XIANG ; . YU CHEN ; Heartland Assays. Inc. Ames. Information Management Services Inc. Silver Spring. MD. USA ; New York University Cancer Institute. New York. NY. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 172, n° 1, 2010) |
| Pagination : | 94-106 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Facteur risque ; Risque ; Vitamine D ; Enquête cas témoin ; Epidémiologie ; Oesophage ; Etude prospective |
| Résumé : | [BDSP. Notice produite par INIST-CNRS mo89R0xC. Diffusion soumise à autorisation]. Upper gastrointestinal (GI) cancers of the stomach and esophagus have high incidence and mortality worldwide, but they are uncommon in Western countries. Little information exists on the association between vitamin D and risk of upper GI cancers. This study examined the association between circulating 25-hydroxyvitamin D (25 (OH) D) and upper GI cancer risk in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25 (OH) D were measured from 1,065 upper GI cancer cases and 1,066 age-sex-race-and season-of blood draw-matched controls from 8 prospective cohort studies. In multivariate-adjusted models, circulating 25 (OH) D concentration was not significantly associated with upper GI cancer risk. Subgroup analysis by race showed that among Asians, but not Caucasians, lower concentrations of 25 (OH) D (<25 nmol/L) were associated with a statistically significant decreased risk of upper GI cancer (reference : 50-<75 nmol/L) (odds ratio=0.53,95% confidence interval : 0.31,0.91 ; P trend=0.003). Never smokers with concentrations of<25 nmol/L showed a lower risk of upper GI cancers (odds ratio=0.55,95% confidence interval : 0.31,0.96). Subgroup analyses by alcohol consumption produced opposing trends. Results do not support the hypothesis that interventions aimed at increasing vitamin D status would lead to a lower risk of these highly fatal cancers. |
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