| Titre : | Parents'Ages at Birth and Risk of Adult-onset Hematologic Malignancies Among Female Teachers in California. (2010) |
| Auteurs : | . YANI LU ; Leslie BERNSTEIN ; Ellen-T CHANG ; Christina-A CLARKE ; Katherine-D HENDERSON ; . HUIYAN MA ; Susan-L NEUHAUSEN ; Jane SULLIVAN-HALLEY ; Sophia-S WANG ; Dee-W WEST ; Cancer Prevention Institute of California. Fremont. CA. USA ; Department of Population Sciences. Beckman Research Institute. City of Hope. Duarte. CA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 171, n° 12, 2010) |
| Pagination : | 1262-1269 |
| Langues: | Anglais |
| Mots-clés : | Leucémie ; Parent ; Age mère naissance ; Naissance ; Facteur risque ; Risque ; Adulte ; Femme ; Enseignant ; Epidémiologie ; Homme ; Amérique ; Cancer ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST-CNRS D8tHoR0x. Diffusion soumise à autorisation]. Although advanced parental age at one's birth has been associated with increased risk of breast and prostate cancers, few studies have examined its effect on adult-onset sporadic hematologic malignancies. The authors examined the association of parents'ages at women's births with risk of hematologic malignancies among 110,999 eligible women aged 22-84 years recruited into the prospective California Teachers Study. Between 1995 and 2007,819 women without a family history of hematologic malignancies were diagnosed with incident lymphoma, leukemia (primarily acute myeloid leukemia), or multiple myeloma. Multivariable-adjusted Cox proportional hazards models provided estimates of relative risks and 95% confidence intervals. Paternal age was positively associated with non-Hodgkin lymphoma after adjustment for race and birth order (relative risk for age>=40 vs.<25 years=1.51,95% confidence interval : 1.08,2.13 ; P-trend=0.01). Further adjustment for maternal age did not materially alter the association. By contrast, the elevated non-Hodgkin lymphoma risk associated with advanced maternal age (>40 years) became null when paternal age was included in the statistical model. No association was observed for acute myeloid leukemia or multiple myeloma. Advanced paternal age may play a role in non-Hodgkin lymphoma etiology. Potential etiologic mechanisms include de novo gene mutations, aberrant paternal gene imprinting, or telomere/telomerase biology. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact