| Titre : | Body Fatness at Young, Ages and Risk of Breast Cancer Throughout Life. (2010) |
| Auteurs : | BAER (Heather-J) : USA. Division of General Medicine and Primary Care. Brigham and Women's Hospital. Boston. MA. ; Susan-E HANKINSON ; Shelley-S TWOROGER ; WILLETT (Walter-C) : USA. Department of Nutrition. Harvard School of Public Health. Boston. MA. |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 171, n° 11, 2010) |
| Pagination : | 1183-1194 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Obésité ; Corps ; Age ; Facteur risque ; Risque ; Sein ; Tissu adipeux ; Adolescent ; Enfance à risque ; Enfant ; Epidémiologie ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS k9R0xosk. Diffusion soumise à autorisation]. Body fatness at young ages may be related to breast cancer risk independently of adult adiposity. The authors conducted a prospective analysis among 188,860 women (7,582 breast cancer cases) in the Nurses'Health Study (1988-2004) and Nurses'Health Study II (1989-2005) who recalled their body fatness at ages 5,10, and 20 years using a 9-level pictogram (level 1 : most lean ; level 9 : most overweight). Body fatness at young ages was inversely associated with risk of both premenopausal and postmenopausal breast cancer (per 1-unit increase in adolescent body fatness, relative risk (FIR)=0.88 and RR=0.91, respectively ; Ptrend<0.0001). Among all women, the RR for adolescent body fatness of level 6.5 or higher versus level 1 was 0.57 (per 1-unit increase, RR=0.90 ; Ptrend<0.0001) and was unaffected by adjustment for current body mass index. The association was stronger for women with birth weights under 8.5 pounds (<3.9 kg) than for women with birth weights of 8.5 pounds or more (>3.9 kg) (per 1-unit increase, RR=0.89 and RR=0.94, respectively ; Pinteraction=0.04) and stronger for estrogen receptor-negative tumors than for estrogen receptor-positive tumors (per 1-unit increase, RR=0.86 and RR=0.92, respectively ; Pheterogeneity=0.03). Body fatness at young ages has a strong and independent inverse relation to breast cancer risk throughout life. |
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