| Titre : | Reproductive Hormones and Obesity : 9 Years of Observation From the Study of Women's Health Across the Nation. (2010) |
| Auteurs : | Kim SUTTON-TYRRELL ; Janet JOHNSTON ; Bill LASLEY ; Rachel MACKEY ; Karen MATTHEWS ; Nanette SANTORO ; Maryfran SOWERS ; . XINHUA ZHAO |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 171, n° 11, 2010) |
| Pagination : | 1203-1213 |
| Langues: | Anglais |
| Mots-clés : | Obésité ; Femme ; Ménopause ; Reproduction ; Epidémiologie ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 8tGR0xrm. Diffusion soumise à autorisation]. The effect of change in reproductive hormones and menopause on incident obesity (body mass index>=30 kg/m2) and severe obesity (body mass index>=35 kg/m2) was evaluated over 9 years in 3,260 US women recruited in the multiethnic Study of Women's Health Across the Nation in 1996-1997. After 9 years, cumulative incidences of obesity and severe obesity reached 21.8% and 12.3%, respectively. In multivariate analysis, hormone changes, chronic health conditions, lower physical activity, race/ethnicity, and age were significantly associated with incident obesity and/or severe obesity. The odds of incident severe obesity increased with surgical menopause (odds ratio (OR)=5.07,95% confidence interval (CI) : 2.29,11.20 ; P<0.001) and initiation of hormone therapy prior to 12 months of amenorrhea (OR=2.94,95% CI : 1.14,7.58 ; P=0.03). Predictors of obesity included an increase in free androgen index (OR=1.37,95% CI : 1.12,1.68 ; P=0.002) and a decrease in sex hormone-binding globulin (OR=0.60,95% CI : 0.45,0.80 ; P=0.0005). Similar results were found for severe obesity. Obesity rates varied by race, but no hormone-by-race interactions were observed. These longitudinal data demonstrate that higher androgens, lower sex hormone-binding globulin, surgical menopause, and early hormone therapy use predict incident obesity and/or severe obesity in a multiracial cohort of women transitioning into menopause. |
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