| Titre : | Long-term effects of mammography screening : updated overview of the Swedish randomised trials. Commentary. (2002) |
| Auteurs : | Lennarth NYSTROM ; Ingvar ANDERSSON ; Nils BJURSTAM ; J.A.N. FRISELL ; K.A. GELMON ; B.O. NORDENSKJOLD ; I. OLIVOTTO ; Lars-Erik RUTQVIST |
| Type de document : | Article |
| Dans : | Lancet (The) (vol. 359, n° 9310, 2002) |
| Pagination : | 904-919 (13p.) |
| Langues: | Anglais |
| Mots-clés : | Mammographie ; Dépistage ; Cancer ; Sein ; Evolution ; Mortalité ; Incidence ; Epidémiologie ; Suède ; Europe ; Adulte ; Homme ; Personne âgée ; Femme ; Radiodiagnostic |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 83s5R0x1. Diffusion soumise à autorisation]. Background There has been much debate about the value of screening mammography. Here we update the overview of the Swedish randomised controlled trials on mammography screening up to and including 1996. The Kopparberg part of the Two-County trial was not available for the overview, but the continuation of the Malmö trial (MMST II) has been added. The article also contains basic data from the trials that have not been presented before. Methods The trials (n=247 010, invited group 129 750, control group 117 260) have been followed up by record linkage to the Swedish Cancer and Cause of Death Registers. The relative risks (RR) for breast cancer death and mortality were calculated for the invited and the control groups. The trial-specific as well as the age-specific effects were analysed. RRs were calculated by the density method, with total person-time experience of the cohort by time interval of follow-up as a basis for estimating mortality rates. We calculated weighted RRs and 95% Cl with the Mantel-Haenszel procedure. Findings The median trial time-the time from randomisation until the first round was completed for the control group or if the control group was not invited, until end of follow-up-was 6.5 years (range 3.0-18.1). The median follow-up time, the time from randomisation, to the end of follow-up, was 15.8 years (5.8-20.2). There were 511 breast cancer deaths in 1 864 770 women-years in the invited groups and 584 breast cancer deaths in 1 688 440 women-years in the control groups, a significant 21% reduction in breast cancer mortality (RR=0.79,95% Cl 0.70-0.89). The reduction was greatest in the age group 60-69 years at entry (33%). Looking at 5-year age groups, there were statistically significant effects in the age groups 55-59,60-64, and 65-69 years (RR=0.76,0.68, and 0.69, respectively). There was a small effect in women 50-54 years at randomisation (RR=0.95). (...) |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact