| Titre : | Age and severe adverse drug reactions caused by nifedipine and verapamil. (1996) |
| Auteurs : | M. PAHOR ; P. CARBONIN ; L. CAROSELLA ; J.M. GURALNIK ; A. MANTO ; C. PEDONE ; Department of Internal Medicine and Geriatrics. Catholic University. Rome. ITA |
| Type de document : | Article |
| Dans : | Journal of clinical epidemiology (vol. 49, n° 8, 1996) |
| Pagination : | 921-928 |
| Langues: | Anglais |
| Mots-clés : | Epidémiologie ; Age ; Homme ; Hôpital ; Italie ; Europe ; Pharmacovigilance |
| Résumé : | [BDSP. Notice produite par INIST 3uIR0xXN. Diffusion soumise à autorisation]. The association of age with risk for severe adverse drug reactions (SADRs) was studied in 2371 and 862 hospitalized patients taking nifedipine and verapamil, respectively. Nifedipine caused hypotension (n=22), tachycardia (n=3), and acute renal failure (n=1) (total SADR rate, 1.1%, 26/2371). Verapamil caused hypotension (n=3), bradycardia (n=9), and atrioventricular blocks (n=2) (total SADR rate, 1.6%, 14/862). The mean age of patients with and without SADRs was for nifedipine 77.1 1.7 and 71.8 0.8 years, respectively (p<0.05), and for verapamil 73.4 2.9 and 73.1 0.4 years, respectively. Sex, length of stay, comorbidity, polypharmacy, intake of slow-release preparations, daily dosage, and new intake of calcium antagonists were examined as potential confounders of the age-SADR association. After adjusting for potential confounders, age was signficantly and independently associated with SADRs caused by nifedipine, but not with SADRs caused by verapamil (OR=1.69,95% CI=1.05-2.72 and OR=1.06,95% CI=0.63-1.68 for 10-year increase, respectively). Although nifedipine and verapamil did not have significantly different rates of SADRs, an age-related gradient was found only for nifedipine. |
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