| Titre : | Insulin sensitivity and blood pressure in a biethnic sample : The Miami community health study. (1996) |
| Auteurs : | R.P. Donahue ; J. BEAN ; R.A. DECARLO DONAHUE ; M. GUTT ; R.J. PRINEAS ; N. SCHNEIDERMAN ; J.S. SKYLER ; Department of Epidemiology and Public Health. School of Medicine. Miami Florida. USA |
| Type de document : | Article |
| Dans : | Journal of clinical epidemiology (vol. 49, n° 8, 1996) |
| Pagination : | 859-864 |
| Langues: | Anglais |
| Mots-clés : | Insuline ; Ethnie ; Epidémiologie ; Etats Unis ; Amérique ; Homme |
| Résumé : | [BDSP. Notice produite par INIST DZVVR0xx. Diffusion soumise à autorisation]. An association between blood pressure and insulin sensitivity among normotensive African-Americans has not been demonstrated consistently in epidemiologic studies. Part of the discrepancy may be due to studying persons with profound obesity-an insulin-resistant state itself. The association between insulin-mediated glucose uptake (i.e., insulin sensitivity) and blood pressure was examined among 25 nondiabetic African-American and 28 white non-Hispanic persons aged 25-44 years who ranged from normal weight to obese, using the hyperinsulinemic euglycemic clamp technique. In bivariate analyses, insulin sensitivity was inversely related to systolic (p<0.01) and diastolic blood pressure (p=0.08) among African-American persons and to diastolic blood pressure among white non-Hispanic subjects (p<0.05). Covariate adjustment for age and sex had only a marginal effect on these results. When the data were pooled and further adjusted for ethnicity, insulin sensitivity remained significantly associated with both systolic and diastolic blood pressure (p<0.01 for each). To consider the effect of obesity, body mass index (BMI) was divided at the sample median (26.5 kg/m2) and the analyses were repeated within each stratum. Among those whose BMI was below the median value, each increment in insulin sensitivity was associated with a 2-mmHg decrease in systolic blood pressure (p=0.02). (...) |
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