| Titre : | Role of Anxiety and depression in the onset of spontaneous preterm labor. Commentary. Authors'reply. (2002) |
| Auteurs : | J. DAYAN ; E. BARANGER ; C. CREVEUIL ; C. HERBEL ; M. HERLICOVIEZ ; George-A MACONES ; C. SAVOYE ; A. THOUIN ; Laboratoire d'Informatique Médicale et Epidémiologie. Chu Clemenceau. Caen. FRA ; Service de Psychiatrie de l'Enfant et de l'Adolescent. Chu Clemenceau. Caen. FRA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 155, n° 4, 2002) |
| Pagination : | 293-304 |
| Langues: | Anglais |
| Mots-clés : | Etat dépressif ; Prématurité ; Epidémiologie ; Facteur risque ; Incidence ; Homme ; Femme ; Mère ; France ; Europe ; Trouble humeur ; Foetopathie ; Gestation [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xoU16U. Diffusion soumise à autorisation]. The aim of this cohort study conducted in France in 1997-1998 was to investigate the effects of antenatal anxiety and depression on spontaneous preterm labor. A consecutive series of 634 pregnant women with singleton pregnancies was included. Anxiety and depression were assessed using self-administered questionnaires : Spielberger's State-Trait Anxiety Inventory and the Edinburgh depression scale. Depression scores were dichotomized with a cutoff value suggestive of major depression. The 75th percentile was used for anxiety scores. A logistic regression analysis, controlling for sociodemographic and biomedical factors and including interaction terms, revealed that depression was positively associated with the outcome among underweight women, defined as women with a prepregnancy body mass index below 19 (adjusted odds ratio (OR)=6.9,95% confidence interval (CI) : 1.8,26.2). A similar result was observed for trait anxiety in women with a history of preterm labor (adjusted OR=4.8,95% Cl : 1.1,20.4). The association was close to significance for state anxiety in women with vaginal bleeding (adjusted OR=3.6,95% CI : 0.9,14.7). These findings show that anxiety and depression, when combined with specific biomedical factors, are associated with spontaneous preterm labor. A synergic action of psychological and biomedical factors on the secretion of placental corticotropin-releasing factor is hypothesized. |
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