| Titre : | Chlamydia pneumoniae antibodies in chronic obstructive pulmonary disease. (1996) |
| Auteurs : | L. VON HERTZEN ; R. ISOAHO ; S.L. KIVELA ; R. KOSKINEN ; P. LAIPPALA ; M. LEINONEN ; P. SAIKKU ; M. TOYRYLA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 25, n° 3, 1996) |
| Pagination : | 658-664 |
| Langues: | Anglais |
| Mots-clés : | Epidémiologie ; Etiologie ; Bactériose ; Infection ; Bactérie ; Personne âgée ; Homme ; Finlande ; Europe ; Appareil respiratoire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST TXZhuR0x. Diffusion soumise à autorisation]. Background. The significance of persistent or recurrent respiratory infections in adult life for the development of chronic obstructive pulmonary disease (COPD) is still to a large extent unknown. A few clinical and experimental animal studies suggest that peripheral airways diseases may be due to the cumulative effects of recurrent respiratory infections over an extended period. Methods. C. pneumoniae-specific IgG and IgA antibody levels were determined in two elderly groups of male patients with COPD and in control subjects without the disease. The first group (N=36) consisted of patients who were hospitalized due to an acute exacerbation of COPD. The second group of patients (N=54) and the controls (N=321) were participants in a community survey on respiratory diseases in the elderly. The criteria for seropositivity were defined as an IgG titre of 32 and an IgA titre of 16. Results. 89% of the hospitalized patients (group 1) and 66% of the non-hospitalized patients (group II) were IgA-seropositive as compared to 55% of the controls. Derived from the logistic regression analysis, the odds ratio (OR) was 7.4 (95% Cl : 2.1-25.7) between group I and the controls and 1.5 (0.7-2.9) between group II and the controls. Furthermore, the difference in the age-adjusted geometric mean titres (GMT) of IgA antibodies between the group I and the controls was significant (53.0 for the patients versus 19.1 for the controls). (...) |
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