Titre :
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Prior spontaneous abortion, prior elective termination, interpregnancy interval, and risk of neural tube defects. (2000)
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Auteurs :
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K. TODOROFF ;
G.M. SHAW ;
California Birth Defects Monitoring Program. March of Dimes Birth Defects Foundation. Emeryville. CA. USA
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 151, n° 5, 2000)
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Pagination :
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505-511
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Langues:
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Anglais
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Mots-clés :
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Anencéphalie
;
Nouveau né
;
Homme
;
Femme
;
Grossesse
;
Mère
;
Epidémiologie
;
Facteur risque
;
Etats Unis
;
Amérique
;
Avortement
;
Système nerveux [pathologie]
;
Maladie congénitale
;
Malformation tube neural
;
Malformation
;
Gestation [pathologie]
;
Amérique du Nord
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Résumé :
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[BDSP. Notice produite par INIST 0mf5R0xP. Diffusion soumise à autorisation]. A woman with a history of spontaneous abortion in her immediately prior pregnancy may be at increased risk for a pregnancy affected by a neural tube defect (NTD). A short interpregnancy interval may further increase this risk. Using data from a population-based case-control study (1989-1991), the authors investigated NTD risk resulting from a prior spontaneous abortion or elective termination and a short interpregnancy interval. Of 538 interviewed case mothers and 539 interviewed control mothers, 408 case mothers and 433 control mothers reported having a prior pregnancy. Analysis showed a slightly decreased NTD risk among mothers whose immediately prior pregnancy had ended in a spontaneous abortion or elective termination in comparison with a live birth (odds ratio (OR)=0.82 ; 95% confidence interval (Cl) : 0.61,1.1). This decreased risk was consistent across strata of short or long interpregnancy intervals. Additional analysis revealed an increased NTD risk for mothers with an interpregnancy interval of 12-
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