| Titre : | Association between gastric cancer mortality and nitrate content of drinking water : Ecological study on small area inequalities. (2001) |
| Auteurs : | Janos SANDOR ; Istvan EMBER ; Orsolya FARKAS ; Istvan KISS ; Department of Public Health. University of Pecs. Pecs. HUN |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 17, n° 5, 2001) |
| Pagination : | 443-447 |
| Langues: | Anglais |
| Mots-clés : | Epidémiologie ; Mortalité ; Homme ; Cancer ; Estomac ; Nitrate ; Eau consommation humaine ; Hongrie ; Europe ; Santé environnementale ; Carcinogène ; Appareil digestif [pathologie] ; Estomac [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS SNmyR0xC. Diffusion soumise à autorisation]. The carcinogenic feature of N-nitroso compounds has been well established. Similarly, the transformation of ingested nitrate to N-nitroso compounds in the stomach has been thoroughly documented, nevertheless nitrates'carcinogenic effect has not been proved convincingly in human. The present study was aimed to investigate a population of small villages provided by drinking water with high and widely variable nitrate content (72 mg/l median, 290.7 mg/l 95-percentile concentration). Empirical Bayes estimates for settlement-specific age-sex-and year-standardised mortality ratios of gastric cancer (GC) were related to the settlement level average nitrate concentrations in drinking water controlling for confounding effects of smoking, ethnicity and education. The log-transformed average nitrate concentration showed significant positive association with stomach cancer mortality in linear regression analysis (p=0.014). The settlements were aggregated according to the nitrate concentration into 10-percentile groups and the standardised mortality ratios (SMRs) were calculated. Those groups with higher than 88 mg/l average nitrate concentration showed substantial risk elevation and the log-transformed exposure variables proved to be significant predictors of mortality (p=0.032) at this level of aggregation also. The association seemed to be fairly strong (r2=0.46). Although this investigation constituting an ecological study has certain limitations, it supports the hypothesis that the high level of nitrate in drinking water is involved in the development of GC. |
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