| Titre : | Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women : Results from the National Osteoporosis Risk assessment. (2001) |
| Auteurs : | Ethel-S SIRIS ; Thomas-A Abbott ; Elizabeth BARRETT-CONNOR ; Marc-L Berger ; Kenneth-G FAULKNER ; Paul-D MILLER ; Arthur-C SANTORA ; Louis-M SHERWOOD ; Lois-E WEHREN ; Merck & Co Inc. West Point. PA. USA |
| Type de document : | Article |
| Dans : | JAMA - Journal of the american medical association (vol. 286, n° 22, 2001) |
| Pagination : | 2815-2822 |
| Langues: | Anglais |
| Mots-clés : | Ménopause ; Facteur risque ; Complication ; Ostéoporose ; Examen complémentaire ; Epidémiologie ; Incidence ; Os ; Prévalence ; Diagnostic ; Adulte ; Homme ; Femme ; Etats Unis ; Amérique ; Système ostéoarticulaire [pathologie] ; Ostéopathie ; Traumatisme ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST-CNRS V5R0xT9z. Diffusion soumise à autorisation]. Context : Large segments of the population at risk for osteoporosis and fracture have not been evaluated, and the usefulness of peripheral measurements for short-term prediction of fracture risk is uncertain. Objectives : To describe the occurrence of low bone mineral density (BMD) in postmenopausal women, its risk factors, and fracture incidence during short-term follow-up. Design : The National Osteoporosis Risk Assessment, a longitudinal observational study initiated September 1997 to March 1999, with approximately 12 months of subsequent follow-up. Setting and Participants : A total of 200160 ambulatory postmenopausal women aged 50 years or older with no previous osteoporosis diagnosis, derived from 4236 primary care practices in 34 states. Main Outcome Measures : Baseline BMD T scores, obtained from peripheral bone densitometry performed at the heel, finger, or forearm ; risk factors for low BMD, derived from questionnaire responses ; and clinical fracture rates at 12-month follow-up. Results : Using World Health Organization criteria, 39.6% had osteopenia (T score of - 1 to - 2.49) and 7.2% had osteoporosis (T score<=-2.5). Age, personal or family history of fracture, Asian or Hispanic heritage, smoking, and cortisone use were associated with significantly increased likelihood of osteoporosis ; higher body mass index, African American heritage, estrogen or diuretic use, exercise, and alcohol consumption significantly decreased the likelihood. Among the 163979 participants with follow-up information, osteoporosis was associated with a fracture rate approximately 4 times that of normal BMD (rate ratio, 4.03 ; 95% confidence interval [Cl], 3.59-4.53) and osteopenia was associated with a 1.8-fold higher rate (95% Cl, 1.49-2.18). Conclusions : Almost half of this population had previously undetected low BMD, including 7% with osteoporosis. (...) |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact