Psychotic illness in people with Prader Willi synd... Catalogue en ligne

Titre :	Psychotic illness in people with Prader Willi syndrome due to chromosome 15 maternal uniparental disomy. (2002)
Auteurs :	Harm BOER ; Jill BUTLER ; David CLARKE ; Anthony HOLLAND ; Tessa WEBB ; Joyce WHITTINGTON ; Section of Developmental Psychiatry. Department of Psychiatry. University of Cambridge. Cambridge. GBR
Type de document :	Article
Dans :	Lancet (The) (vol. 359, n° 9301, 2002)
Pagination :	135-136
Langues:	Anglais
Mots-clés :	Psychose ; Génétique ; Mère ; Epidémiologie ; Facteur risque ; Maladie associée ; Homme ; Glande endocrine [pathologie] ; Système ostéoarticulaire [pathologie] ; Maladie héréditaire ; Aberration chromosomique
Résumé :	[BDSP. Notice produite par INIST-CNRS MU5a9R0x. Diffusion soumise à autorisation]. In a population-based study of Prader Willi syndrome (PWS), we investigated the relation between genetic subtypes of the syndrome and psychiatric morbidity. Of 25 patients aged 18 years or older, seven (28%) had severe affective disorder with psychotic features, with a mean age of onset of 26 years (SD 5.9). The seven people affected, all aged 28 years or older, Included all five with disomies of chromosome 15, one with a deletion In this chromosome, and one with an imprinting centre mutation In the same chromosome. We postulate that in PWS, an abnormal pattern of expression of a sex-specific imprinted gene on chromosome 15 is associated with psychotic illness in early adult life.

PORTAIL DOCUMENTAIRE