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Résumé :
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[BDSP. Notice produite par INIST-CNRS trR0xj4B. Diffusion soumise à autorisation]. A hospital-based case-control study of 295 cases with histologically confirmed gastric cancer and age and sex-matched controls was conducted to evaluate the effect of dietary vitamin C intake upon the relation between Helicobacter pylori infection and gastric cancer in Korea in 1997-1998. Anti-H. pylori IgG was detected by ELISA. A food frequency questionnaire, and a questionnaire on demographic factors, including past medical history, smoking, alcohol consumption, and life style was also administered. The prevalences of H. pylori IgG in cases and controls were 80.7% and 71.2%, respectively, and the odds ratio (OR) of H. pylori for gastric cancer was 1.68 (95% confidence interval (CI) : 1.14,2.44), after adjusting for age, sex, educational level, and a past medical history of gastritis or gastric ulcer. In a stratified analysis, H. pylori seropositivity was found to be a significant risk factor for gastric cancer in the low vitamin C intake group (OR=4.68 ; 95% CI : 1.97,11.1), but not in the high vitamin C intake group (OR=0.72 ; 95% CI : 0.32,1.65). Vitamin C intake was found to modify the relation between H. pylori and gastric cancer.
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