| Titre : | Contribution of influenza and respiratory syncytial virus to community cases of influenza-like illness : an observational study. Commentary. (2001) |
| Auteurs : | M.C. ZAMBON ; J.P. CLEWLEY ; D.M. FLEMING ; Eric-Af SIMOES ; J.D. STOCKTON ; Virus Reference Division. Phls Central Public Health Laboratory. London. GBR |
| Type de document : | Article |
| Dans : | Lancet (The) (vol. 358, n° 9291, 2001) |
| Pagination : | 1382-1416 (9p.) |
| Langues: | Anglais |
| Mots-clés : | Grippe ; Virose ; Infection ; Virus ; Appareil respiratoire ; Incidence ; Epidémiologie ; Royaume Uni ; Europe ; Diagnostic ; Adulte ; Homme ; Enfant ; Appareil respiratoire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 632R0x81. Diffusion soumise à autorisation]. Background Respiratory syncytial virus (RSV) is an important cause of lower-respiratory-tract infection in children and elderly people, but its effect in other age-groups is uncertain. We did a community-based observational study of RSV infection in community-dwelling individuals of all ages who presented to general practices in the UK with influenza-like illnesses during three successive winters (1995-96,1996-97, and 1997-98). Methods Nasopharyngeal swabs routinely submitted for virological surveillance were examined by multiplex reverse transcription PCR for influenza A and B viruses and RSV A and B, and findings were related to the clinical incidence of influenza-like illness and acute bronchitis at that time. RSV strains identified were compared with those obtained from hospital admissions. Findings 480 RSV and 709 influenza viruses were identified from a total of 2226 swabs submitted. Both types of virus were found in all age-groups for between 12 and 20 weeks in each winter. RSV A accounted for 60% of RSV detections. Similar strains of RSV were present in hospital and community patients within the same year, but there were different lineages each year. Interpretation In individuals diagnosed with influenza-like illness, there is a substantial potential for confusion between illnesses caused by influenza and those caused by RSV. The burden of illness attributable to each needs to be clarified to define optimum management routines. |
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