| Titre : | Impact of first-line vs second-line antibiotics for the treatment of acute uncomplicated sinusitis. (2001) |
| Auteurs : | Jay-F PICCIRILLO ; Robert-H BROPHY ; Mark-E FRISSE ; Andrew GOGGIN ; Douglas-E MAGER ; Express Scripts Inc. Maryland Heights. MO. USA |
| Type de document : | Article |
| Dans : | JAMA - Journal of the american medical association (vol. 286, n° 15, 2001) |
| Pagination : | 1849-1856 |
| Langues: | Anglais |
| Mots-clés : | Sinusite ; Thérapeutique ; Analyse coût efficacité ; Médicament antibiotique ; Thérapeutique médicamenteuse ; Chimiothérapie ; Pronostic ; Homme ; ORL [pathologie] ; Economie santé |
| Résumé : | [BDSP. Notice produite par INIST-CNRS uBR0xL9v. Diffusion soumise à autorisation]. Context Studies suggest little benefit in relief of acute sinusitis symptoms from the use of newer and more expensive (second-line) antibiotics instead of older and less expensive (first-line) antibiotics. However, researchers have failed to include development of complications and cost of care in their analyses. Objective To compare the effectiveness and cost of first-line with second-line antibiotics for the treatment of acute uncomplicated sinusitis in adults. Design, Setting, and Patients Retrospective cohort study using a pharmaceutical database containing demographic, clinical (International Classification of Diseases, Ninth Revision), treatment, and charge information for 29102 adults with a diagnosis of acute sinusitis receiving initial antibiotic treatment between July 1,1996, and June 30,1997. Main Outcome Measures Absence of additional claim for an antibiotic in the 28 days after the initial antibiotic, presence of a claim for a second antibiotic, serious complications of sinusitis, and direct charges and use for the acute sinusitis treatment. Results There were 17 different antibiotics prescribed in this study. The majority (59.5%) of patients received 1 of the first-line antibiotics. The overall success rate was 90.4% (95% confidence interval [CI], 90.0% - 90.8%). The success rate for the 17 329 patients who received a first-line antibiotic was 90.1% and for the 11773 patients who received a second-line antibiotic was 90.8%, a difference of 0.7% (95% CI, 0.01% - 1.40% ; P<. 05). There were 2 cases of periorbital cellulitis, one in each treatment group. The average total direct charge for patients receiving a first-line antibiotic was $68.98 and a second-line antibiotic was $135.17, a difference of $66.19 (95% CI, $64.95-67.43 ; P<. 001). (...) |
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