Titre : | Apparent prevention of neural tube defects by periconceptional vitamin supplementation. (2011) |
Auteurs : | R.W. SMITHELLS ; D.W. FIELDING ; R. HARRIS ; N.C. NEVIN ; A.P. READ ; C.J. SCHORAH ; M.J. SELLER ; S. SHEPPARD ; Department of Medical Genetics. Queen's University of Belfast ; Department of Medical Genetics. University of Manchester. GBR ; Department of Paediatrics and Child Health. University of Leeds ; Paediatric Research Unit. Guy's Hospital. London. GBR ; Department of Paediatrics. Chester. GBR |
Type de document : | Article |
Dans : | International journal of epidemiology (vol. 40, n° 5, 2011) |
Pagination : | 1146-1154 |
Langues: | Anglais |
Mots-clés : | Prévention santé ; Vitamine ; Supplémentation ; Malformation |
Résumé : | [BDSP. Notice produite par INIST-CNRS DR0xs8C9. Diffusion soumise à autorisation]. An earlier preliminary paper is expanded. Women who had given birth to one or more infants with a neural tube defect were recruited into a trial of periconceptional vitamin supplementation. Two hundred mothers attending five centres were fully supplemented (FS), 50 were partially supplemented (PS), and 300 were unsupplemented (US). Neural tube defect recurrences in the study pregnancies were 1 (0.5%), in FS, none in PS, and 13 (4%) in US mothers. The difference in outcome between FS and US mothers is significant. The most likely explanation is that supplementation has prevented some neural tube defects, but further studies are needed. |