| Titre : | Coffee and Amyotrophic Lateral Sclerosis : A Possible Preventive Role. (2011) |
| Auteurs : | Ettore BEGHI ; Adriano CHIO ; CORBO (Massimo) : ITA. Fondazione Serena. Centro Clinico Nemo. Hospital Ca'Granda. Milan. ; Giorgia GIUSSANI ; LOGROSCINO (Giancarlo) : ITA. Department of Neurology and Psychiatry. Faculty of Medicine. University of Bari. Bari. ; Paolo MESSINA ; Cristina MOGLIA ; Elisabetta PUPILLO ; ZOCCOLELLA (Stefano) : ITA. Clinic of Nervous System Diseases. Department of Medical and Neurological Sciences. Faculty of Medicine. University of Foggia. Foggia. ; Centro Regionale Esperto per la Sla. Department of Neuroscience. Faculty of Medicine. University of Turin. And San Giovanni Battista Hospital. Turin. ITA ; Laboratory of Neurological Disorders. Mario Negri Institute. Milan. ITA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 174, n° 9, 2011) |
| Pagination : | 1002-1008 |
| Langues: | Anglais |
| Mots-clés : | Maladie Charcot ; Café ; Prévention santé ; Epidémiologie ; Maladie dégénérative |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 9IpnR0xr. Diffusion soumise à autorisation]. The relation between coffee intake and risk of amyotrophic lateral sclerosis (ALS) was investigated in 377 newly diagnosed ALS patients from 4 Italian population-based registries in the European ALS Consortium (EURALS Group) (2007-2010). For each patient, 2 age-and sex-matched hospital controls were selected, one from a neurology department and one from a nonneurologic department. Two additional healthy control groups were identified from local general practitioners' (GPs') lists (n=99) and residents of the same area as a cancer cohort (n=7,057). Coffee intake was defined in terms of status (ever consuming coffee daily for>=6 months vs. never), duration, and history (never, former, or current). Ever coffee drinkers comprised 74.7% of ALS patients, 80.4% of neurologic controls, 85.6% of nonneurologic controls (P=0.0004), 88.9% of GP controls (P=0.0038), and 86.0% of cancer cohort controls (P<0.0001). Current coffee drinkers comprised 60.2% of ALS patients, 70.2% of neurologic controls (P=0.0294), 76.4% of nonneurologic controls (P<0.0001), and 82.3% of GP controls (P=0.0002) ; duration of intake was>30 years for 62.3%, 67.7%, 74.7%, and 72.6%. ALS patients had lower lifetime coffee exposure : Odds ratios were 0.7 (95% confidence interval (CI) : 0.5,1.1), 0.6 (95% CI : 0.4,0.8), and 0.4 (95% CI : 0.2,0.9) in comparison with neurologic, nonneurologic, and GP controls, respectively. In current (vs. never) coffee drinkers, odds ratios were 0.7 (95% CI : 0.5,1.0), 0.5 (95% CI : 0.3,0.7), and 0.4 (95% CI : 0.2,0.8), respectively. These findings provide epidemiologic evidence of an inverse correlation between coffee intake and ALS risk. |
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