| Titre : | Smoking is an independent risk factor for oncogenic human papillomavirus (HPV) infections but not for high-grade CIN. (2007) |
| Auteurs : | Kari SYRJANEN ; Marina BRANOVSKAJA ; Galina CHEMERIS ; Marcella CINTORINO ; Oksana EROKHINA ; Alexandr GRUNBERG ; Valerija GRUNBERGA ; Olga IVANCHENKO ; Anna JUSCHENKO ; Ludmila KLJUKINA ; Vladimir KOZACHENKO ; Elena LIPOVA ; Raisa NEROVJNA ; Maritta NIKITINA ; Julia PAJANIDI ; Nicolay PETROVICHEV ; Jurij PODISTOV ; Alla PSHEPURKO ; Rosa SANTOPIETRO ; Irena SHABALOVA ; Larisa SOZAEVA ; Stina SYRJANEN ; Piero TOSI ; Irena TSIDAEVA ; Sergej ZAKHARENKO ; Tatjana ZAKHAROVA ; Department of Gynaecology. Laboratory of Cytology. Latvian Cancer Centre. Riga. LVA ; Department of Pathology. University of Siena. Siena. ITA ; Nn Blokhin Cancer Research Centre of Russian Academy of Medical Sciences. (R.A.M.S.). Moscow. RUS ; Novgorod Clinical Regional Hospital. Centralised Cytology Laboratory. Novgorod. RUS ; Research Institute of Oncology and Medical Radiology. Republican Centre of Clinical Cytology. Minsk. BLR ; Russian Academy of Post-Graduate Medical Education. Moscow. RUS |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 22, n° 10, 2007) |
| Pagination : | 723-735 |
| Langues: | Anglais |
| Mots-clés : | Tabagisme ; Tabac ; Cancer ; Facteur risque ; Virose ; Histoire ; Historique ; Homme ; Epidémiologie ; Virus ; Infection |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 278BmR0x. Diffusion soumise à autorisation]. Background : Recent evidence implicates smoking as a risk factor for cervical cancer (CC), but the confounding from high-risk human papillomavirus (HPV) infections is not clear. Objectives : To analyse the role of smoking as an independent predictor of CIN2+and HR-HPV infections in a population-based prospective (NIS, New Independent States of former Soviet Union) cohort study. Study design and Methods : A cohort of 3,187 women was stratified into three groups according to their smoking status : (i) women who never smoked ; (ii) those smoking in the past ; and (iii) women who are current smokers. These groups were analysed for predictors of (a) HR-HPV ; (b) high-grade CIN, and (c) outcome of HR-HPV infections and cytological abnormalities during prospective follow-up (n=854). Results : The three groups were significantly different in all major indicators or risk sexual behaviour (or history) implicating strong confounding. There was no increase in HSIL/LSIL/ASC-US cytology or CIN1+/CIN2+/CIN3+among current smokers. Only few predictors of HR-HPV and CIN2+were common to all three groups, indicating strong interference of the smoking status. There was no difference in outcomes of cervical disease or HR-HPV infections between the three groups. In multivariate model, being current smoker was one of the five independent predictors of HR-HPV (P=0.014), with adjusted OR=1.52 (95% CI 1.09-2.14). In addition to age, HR-HPV was the only independent predictor of CIN2+in multivariate model (OR=14.8 ; 95% CI 1.72-127.31). Conclusions : These data indicate that cigarette smoking is not an independent risk factor of CIN2+but the increased risk ascribed to smoking is mediated by acquisition of HR-HPV, of which current smoking was an independent predictor in multivariate model. |
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