| Titre : | Adult socioeconomic position, C-reactive protein and interleukin-6 in the Whitehall II prospective study. (2007) |
| Auteurs : | David GIMENO ; Eric-J BRUNNER ; Jane E. Ferrie ; Gordon-Do LOWE ; Michael-G MARMOT ; Ann RUMLEY ; Division of Cardiovascular and Medical Sciences. University of Glasgow. Royal Infirmary. Glasgow. GBR ; International Institute for Society and Health. Department of Epidemiology and Public Health. University College London. London. GBR |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 22, n° 10, 2007) |
| Pagination : | 675-683 |
| Langues: | Anglais |
| Mots-clés : | Adulte ; Facteur socioéconomique ; Etude prospective ; Inflammation ; Changement ; Epidémiologie ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 1dR0xrs8. Diffusion soumise à autorisation]. Background : Prior studies on the association of inflammatory markers, such as C-reactive protein (CRP) and interleukin-6 (IL-6), with socioeconomic position (SEP) have been cross-sectional. Thus, the question of whether socioeconomic differences in CRP and IL-6 change over time remains unanswered. We examined the relationship between SEP and changes over 12 years in CRP and IL-6. Methods : Data were for 4,750 middle-aged (mean 49.0 years, SD 5.9) civil servants from phases 3 and 7 of the Whitehall II study. Adult SEP was based on last known Civil Service employment grade. Covariates included sociodemographics, behavioural and biological risk factors, presence of diseases/illnesses, prescribed medications, work-related factors, labour market status and early life factors. Results : Steep socioeconomic gradients observed at Phase 3 (p<0.001) persisted in both CRP and IL-6 12 years later after adjustment for other risk factors. Adjustment for behavioural (diet and smoking), biological (mainly body mass index and total : HDL cholesterol ratio) and early life factors resulted in considerable attenuation but the inverse socioeconomic gradients remained statistically significant. Although CRP and IL-6 concentrations increased substantially over the 12-year period at every level of SEP, CRP and IL-6 did not change differentially according to SEP. Conclusion : Despite overall increases in CRP and IL6, relative differences by SEP remained unchanged so that socioeconomic gradients in both sexes persisted over the period observed. |
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