| Titre : | Between-Strain Competition in Acquisition and Clearance of Pneumococcal Carriage : Epidemiologic Evidence From a Longitudinal Study of Day-Care Children. (2010) |
| Auteurs : | Kari AURANEN ; KALTOFT (Margit-S) : DNK. Department of Bacteriology. Mycology and Parasitology. Statens Serum Institut. Copenhagen. ; Juha MEHTALA ; Antti TANSKANEN ; Department of Vaccination and Immune Protection. National Institute for Health and Welfare. Helsinki. FIN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 171, n° 2, 2010) |
| Pagination : | 169-176 |
| Langues: | Anglais |
| Mots-clés : | Clairance ; Epidémiologie ; Hôpital jour ; Enfant ; Réservoir maladie ; Pathologie ; Modèle ; Statistique ; Bactérie ; Streptococcie ; Bactériose ; Infection ; Homme ; Porteur sain |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xpnoGn. Diffusion soumise à autorisation]. The state of pneumococcal carriage-that is, pneumococcal colonization in the nasopharynx of healthy persons-represents a reservoir for the spread of pneumococci among individuals. In light of the introduction of new pneumococcal conjugate vaccines, further knowledge on the dynamics of pneumococcal carriage is important. Different serotypes (strains) of pneumococcus are known to compete with each other in colonizing human hosts. Understanding the strength and mode of between-serotype competition is important because of its implications for vaccine-induced changes in the ecology of pneumococcal carriage. Competition may work through reduced acquisition of new serotypes, due to concurrent carriage in the individual, or through enhanced clearance of serotypes in carriers who harbor more than 1 serotype simultaneously. The authors employed longitudinal data (1999-2001) on pneumococcal carriage in Danish day-care children to analyze between-serotype competition. The data included observations of carriage in children who had not been vaccinated against pneumococcus, and the level of pneumococcal antibiotic resistance and antibiotic usage in the community was very low. Clearance of any single serotype was not affected by simultaneous carriage of other serotypes. In contrast, acquisition of other serotypes in already-colonized hosts was weak (relative rate of acquisition=0.09,95% credible interval : 0.05,0.15). |
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