| Titre : | White Blood Cell Count and Risk of Gastric Cancer Incidence in a General Japanese Population : The Hisayama Study. (2012) |
| Auteurs : | Masahiro IIDA ; Yasufumi DOI ; Jun HATA ; Fumie IKEDA ; Yutaka KIYOHARA ; Mitsuo LIDA ; Takayuki MATSUMOTO ; Toshiharu NINOMIYA ; YONEMOTO (Koji) : JPN. Biostatistics Center. Kurume University. Fukuoka. |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 175, n° 6, 2012) |
| Pagination : | 504-510 |
| Langues: | Anglais |
| Mots-clés : | Sang ; Facteur risque ; Incidence ; Homme ; Japon ; Helicobacter pylori ; Inflammation ; Leucocyte ; Modèle ; Etude prospective ; Epidémiologie ; Asie ; Bactérie ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS JsBDqR0x. Diffusion soumise à autorisation]. The authors examined the association between white blood cell (WBC) count and the development of gastric cancer in a 19-year follow-up study of 2,558 Japanese subjects aged>40 years (1988-2007). The subjects were stratified into 4 groups according to baseline WBC quartile (<4.4,4.5-5.2,5.3-6.3, or>=6.4 x 103 cells/muL). During follow-up, 128 subjects developed gastric cancer. The age-and sex-adjusted incidence of gastric cancer increased linearly with higher WBC level : 1.7,2.6,3.9, and 5.4 per 1,000 person-years, respectively, for the 4 quartile groups (P for trend<0.01). The risk of gastric cancer was 2.22-fold (95% confidence interval : 1.19,4.14) higher in the highest WBC quartile group than in the lowest group after adjustment for confounding factors. With respect to Helicobacter pylori infection status, H. pylori-seropositive subjects in the highest WBC quartile group showed a significantly greater risk of gastric cancer than those in the lower 3 quartile groups, whereas such an association was not observed in H. pylori-seronegative subjects. There was no evidence of heterogeneity in the association (Pfor heterogeneity=0.65). The study findings suggest that higher WBC levels are a risk factor for gastric cancer, especially in subjects with H. pylori infection. |
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