| Titre : | Apolipoprotein E Gene Associations in Age-related Macular Degeneration : The Melbourne Collaborative Cohort Study. (2012) |
| Auteurs : | Madeleine-Km ADAMS ; Khin-Zaw AUNG ; Paul-N BAIRD ; Dallas-R ENGLISH ; Graham-G GILES ; Robyn-H GUYMER ; John HOPPER ; Galina-A MAKEYEVA ; Andrea-J RICHARDSON ; Liubov-D ROBMAN ; Julie-A SIMPSON ; Cancer Epidemiology Centre. Cancer Council of Victoria. Melbourne. Victoria. AUS ; Centre for Molecular. Environmental. Genetic. And Analytic Epidemiology. Melbourne School of Population Health. University of Melbourne. Melbourne. Victoria. AUS |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 175, n° 6, 2012) |
| Pagination : | 511-518 |
| Langues: | Anglais |
| Mots-clés : | Gène ; Génétique ; Association ; Australie ; Vieillissement ; Epidémiologie ; Océanie ; Rétinopathie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS FqR0xoA7. Diffusion soumise à autorisation]. The apolipoprotein E gene (APOE) has been found to be associated with age-related macular degeneration (AMD). Reported associations have been questioned, as they are opposite those for Alzheimer's disease and cardiovascular disease. The authors examined associations between APOE genotype and AMD using a case-control study (2,287 cases and 2,287 controls individually matched on age, sex, and country of origin) nested within Melbourne Collaborative Cohort Study participants aged 48-86 years at AMD detection. The odds ratio for early AMD among participants with epsilon2-containing genotypes (epsilon2epsilon2/epsilon2epsilon3/epsilon2epsilon4) was 1.32 (95% confidence interval (CI) : 1.11,1.58 ; P=0.002) versus persons with genotype epsilon3epsilon3. Associations with early AMD varied by smoking status ; epsilon2-containing genotypes were positively associated with early AMD for never and previous smokers (never smokers : odds ratio (OR)=1.40,95% CI : 1.12,1.76 (P=0.003) ; previous smokers : OR=1.39,95% CI : 1.00,1.93 (P=0.05)) but not for current smokers (OR=0.66,95% CI : 0.34,1.30 (P=0.2 ; interaction P=0.05). The epsilon4-containing genotype group (epsilon3epsilon4/epsilon4epsilon4) had an inverse association with early AMD among current smokers only (OR=0.41,95% CI : 0.22,0.77 (P=0.005)). These results highlight the importance of stratifying by smoking status in elderly populations. Smokers who survive to old age may be more likely to possess unknown genotypes which modify exposure-disease associations. |
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