| Titre : | Menstrual and Reproductive Factors, Exogenous Hormone Use, and Gastric Cancer Risk in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition. (2010) |
| Auteurs : | Eric-J DUELL ; Naomi-E ALLEN ; Kjersti BAKKEN ; Aurelio BARRICARTE ; Manuela-M BERGMAN ; Heiner BOEING ; M.C. BOUTRON-RUAULT ; Hbas BUENO-DE-MESQUITA ; Fatima CARNEIRO ; F. CLAVEL-CHAPELON ; Christina-C DAHM ; Miren DORRONSORO ; Carlos-A GONZALEZ ; Goran HALLMANS ; Mazda JENAB ; Suzanne-M JEURNINK ; Rudolf KAAKS ; Kay-Tee KHAW ; Vittorio KROGH ; Pagona LAGIOU ; Björn LINDKVIST ; Leila LUJAN-BARROSO ; Annekatrin LUKANOVA-MCGREGOR ; Eiliv LUND ; Jonas MANJER ; Amalia MATTIELLO ; Valerie MCCORMACK ; Dominique MICHAUD ; Traci MOUW ; Carmen NAVARRO ; Gabriella NESI ; M.E. NUMANS ; Anja OLSEN ; Kim OVERVAD ; Domenico PALLI ; Petra-Hm PEETERS ; Elio RIBOLI ; Sabina RINALDI ; Laudina RODRIGUEZ ; Carlotta SACERDOTE ; Emilio SANCHEZ-CANTALEJO ; Roger STENLING ; Anne TJONNELAND ; Noémie TRAVIER ; Antonia TRICHOPOULOU ; Konstantinos-K TSILIDIS ; Rosario TUMINO ; Elisabeth VALANOU ; Nicholas WAREHAM |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 172, n° 12, 2010) |
| Pagination : | 1384-1393 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Menstruation ; Facteur risque ; Risque ; Femme ; Europe ; Etude prospective ; Alimentation ; Nutrition ; Reproduction ; Epidémiologie ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS IR0xp8q8. Diffusion soumise à autorisation]. The worldwide incidence of gastric adenocarcinoma (GC) is lower in women than in men. Furthermore, cancer patients treated with estrogens have been reported to have a lower subsequent risk of GC. The authors conducted a prospective analysis of menstrual and reproductive factors, exogenous hormone use, and GC in 335,216 women from the European Prospective Investigation Into Cancer and Nutrition, a cohort study of individuals aged 35-70 years from 10 European countries. After a mean follow-up of 8.7 years (through 2004), 181 women for whom complete exposure data were available developed GC. Adjusted hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards models. All statistical tests were 2-sided. Women who had ovariectomy had a 79% increased risk of GC (based on 25 cases) compared with women who did not (hazard ratio=1.79,95% confidence interval : 1.15,2.78). Total cumulative years of menstrual cycling was inversely associated with GC risk (fifth vs. first quintile : hazard ratio=0.55,95% confidence interval : 0.31,0.98 ; Ptrend=0.06). No other reproductive factors analyzed were associated with risk of GC. The results of this analysis provide some support for the hypothesis that endogenous ovarian sex hormones lower GC incidence in women. |
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