| Titre : | Comprehensive Evaluation of the Impact of 14 Genetic Variants on Colorectal Cancer Phenotype and Risk. (2012) |
| Auteurs : | Steven-J LUBBE ; Peter BRODERICK ; CHANDLER (Ian) : GBR. Department of Histopathology. Royal Devon and Exeter Hospital. Exeter Devon. ; Maria-Chiara DI BERNARDO ; Richard-S HOULSTON ; Section of Cancer Genetics. Institute of Cancer Research. Sutton Surrey. GBR |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 175, n° 1, Janvier 2012) |
| Pagination : | 1-10 |
| Langues: | Anglais |
| Mots-clés : | Evaluation ; Facteur risque ; Risque ; Génétique ; Epidémiologie ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS oB998R0x. Diffusion soumise à autorisation]. To comprehensively evaluate the impact of recently identified colorectal cancer (CRC) variants at 1 q41,3q26.2,8q23.3,8q24.21,10p14,11q23.1,12q13.13,14q22.2,15q13.3,16q22.1,18q21.1,19q13.11,20p12.3, and 20q13.33 on risk and CRC phenotype, the authors analyzed 8,878 cases and 6,051 controls from the United Kingdom ascertained in 1999-2007. The impact of variants on the familial CRC risk was enumerated from age-sex-and calendar-specific CRC rates in the 50,924 first-degree relatives of cases. Each of the 14 susceptibility loci independently influences CRC with the risk increasing with increasing number of risk alleles carried (per allele odds ratio =1.13 ; P =2.99 x 10-58) and, for those within the upper quintile, there is a 2.3-fold increased risk. In first-degree relatives of cases with < =17,18-21, and > =22 risk alleles, standardized incidence ratios were 1.76,2.08, and 2.25, respectively. Although the discriminatory attributes of the 14 CRC susceptibility loci for individual risk prediction are poor (area under the curve =0.58), they may allow subgroups of the population at different CRC risks to be distinguished. |
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