Résumé :
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[BDSP. Notice produite par INIST-CNRS AFFFqR0x. Diffusion soumise à autorisation]. The association between parental smoking and risk of childhood acute lymphoblastic leukemia (ALL) was investigated in an Australian population-based case-control study that included 388 cases and 868 controls aged =15 cigarettes per day around the time of the child's conception was 1.35 (95 % confidence interval : 0.98,1.86). The associations between parental smoking risk of childhood ALL did not differ substantially by immunophenotypic or cytogenetic subtype. Meta-analyses of paternal smoking, including results from the Australian Study of Causes of Acute Lymphoblastic Leukemia in Children and those of previous studies, produced summary odds ratios of 1.15 (95 % confidence interval : 1.06,1.24) for any paternal smoking around the time of the child's conception and 1.44 (95 % confidence interval : 1.24,1.68) for smoking >20 cigarettes per day at that time. Study results suggest that heavier paternal smoking around the time of conception is a risk factor for childhood ALL. Men should be strongly encouraged to cease smoking, particularly when planning to start a family.
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