| Titre : | A Prospective Study of Serum 25-Hydroxyvitamin D Levels, Blood Pressure, and Incident Hypertension in Postmenopausal Women. (2012) |
| Auteurs : | Karen-L MARGOLIS ; Matthew-A ALLISON ; J. DAVID CURB ; Tessa-J KERBY ; Theodore-A KOTCHEN ; Joann-E MANSON ; Lisa-W Martin ; Roberta-M RAY ; . SIMIN LIU ; Sylvia WASSERTHEIL-SMOLLER |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 175, n° 1, Janvier 2012) |
| Pagination : | 22-32 |
| Langues: | Anglais |
| Mots-clés : | Hypertension artérielle ; Etude prospective ; Sérum ; Pression artérielle ; Incidence ; Femme ; Vitamine D ; Epidémiologie ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xB9Hnk. Diffusion soumise à autorisation]. In randomized trials, the effect of vitamin D supplementation on blood pressure has been equivocal, while most prospective cohort studies have shown that the risk of incident hypertension is lower in people with higher levels of 25-hydroxyvitamin D (25 (OH) D). The authors examined the association between levels of 25 (OH) D and changes in blood pressure and incident hypertension in 4,863 postmenopausal women recruited into the Women's Health Initiative between 1993 and 1998. Over 7 years, there were no significant differences in the adjusted mean change in systolic or diastolic blood pressure by quartile of 25 (OH) D. The covariate-adjusted risk of incident hypertension was slightly lower in the upper 3 quartiles of 25 (OH) D compared with the lowest quartile, but this was statistically significant only in the third quartile (hazard ratio =0.67,95 % confidence interval : 0.46,0.96). There was no significant linear or nonlinear trend in the risk of incident hypertension by untransformed or log-transformed continuous values of 25 (OH) D. In postmenopausal women in this study, serum levels of 25 (OH) D were not related to changes in blood pressure, and evidence for an association with lower risk of incident hypertension was weak. |
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