Titre : | Principles and methods for assessing autoimmunity associated with exposure to chemicals. : Critères d'hygiène de l'environnement. |
Auteurs : | World Health Organization (WHO) (Geneva, CHE) ; International Programme on Chemical Safety. (I.P.C.S.). INT |
Type de document : | Ouvrage |
Editeur : | Genève [CHE] : Organisation Mondiale de la Santé (OMS), 2006 |
Collection : | Environmental health criteria , num. 236 |
ISBN : | 978-92-4-157236-1 |
Description : | 333p. |
Langues: | Anglais |
Classement : | CA51/ (Collections "Critères d'hygiène de l'environnement" de l'OMS - Environmental Health Criteria) |
Mots-clés : | Maladie autoimmune ; Système immunitaire ; Anticorps ; Antigène ; Immunité ; Lymphocyte ; Epidémiologie ; Etude ; Santé environnementale ; Médicament ; Génétique ; Hormone |
Résumé : | Autoimmunity is characterized by the reaction of cells (autoreactive T lymphocytes) or products (autoantibodies) of the immune system against the organism's own antigens (autoantigens). Generally autoimmune diseases are perceived to be relatively uncommon. However, when all autoimmune diseases are combined, the estimated prevalence is high (3-5% of the general population), which underlines their importance to public health. Because of difficulties in diagnosis and in designing and standardizing epidemiological studies, limited data are available, and the prevalence may actually be underestimated. Autoimmune diseases are multifactorial. Both intrinsic factors and environmental factors may contribute to the induction, development, and progression of autoimmune diseases. Environmental factors are believed to be a major factor responsible for the increased prevalence. Environmental factors operating in a genetically susceptible host may directly initiate, facilitate, or exacerbate the pathological immune process, induce mutations in genes coding for immunoregulatory factors, or modify immune tolerance or regulatory and immune effector pathways. |
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