| Titre : | Derivation and Validation of the Denver Human Immunodeficiency Virus (HIV) Risk Score for Targeted HIV Screening. (2012) |
| Auteurs : | HAUKOOS (Jason-S) : USA. Department of Epidemiology. Colorado School of Public Health. Aurora. CO. ; Brooke BENDER ; Richard-L BYYNY ; Emily HOPKINS ; Yu-Hsiang HSIEH ; Christopher-J LINDSELL ; Michael-S LYONS ; Lynsay-A MACLAREN ; Richard-E ROTHMAN ; Comilla SASSON ; THRUN (Mark-W) : USA. Denver Public Health. Denver Health Medical Center. Denver. CO. ; Department of Emergency Medicine. Denver Health Medical Center. Denver. CO. USA ; Department of Emergency Medicine. Johns Hopkins Hospital. Baltimore. MD. USA ; Department of Emergency Medicine. School of Medicine. University of Colorado. Aurora. CO. USA ; Department of Emergency Medicine. University of Cincinnati Medical Center. Cincinnati. OH. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 175, n° 8, 2012) |
| Pagination : | 838-846 |
| Langues: | Anglais |
| Mots-clés : | Sida ; VIH ; Facteur risque ; Risque ; Dépistage ; Décision ; Prévalence ; Epidémiologie ; Virose ; Infection ; Rétrovirus ; Virus ; Immunopathologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS tnAIR0xH. Diffusion soumise à autorisation]. Targeted screening remains an important approach to human immunodeficiency virus (HIV) testing. The authors aimed to derive and validate an instrument to accurately identify patients at risk for HIV infection, using patient data from a metropolitan sexually transmitted disease clinic in Denver, Colorado (1996-2008). With multivariable logistic regression, they developed a risk score from 48 candidate variables using newly identified HIV infection as the outcome. Validation was performed using an independent population from an urban emergency department in Cincinnati, Ohio. The derivation sample included 92,635 patients ; 504 (0.54 %) were diagnosed with HIV infection. The validation sample included 22,983 patients ; 168 (0.73 %) were diagnosed with HIV infection. The final score included age, gender, race/ethnicity, sex with a male, vaginal intercourse, receptive anal intercourse, injection drug use, and past HIV testing, and values ranged from - 14 to +81. For persons with scores of <20,20-29,30-39,40-49, and > =50, HIV prevalences were 0.31 % (95 % confidence interval (CI) : 0.20,0.45) (n =27/8,782), 0.41 % (95 % CI : 0.29,0.57) (n =36/8,677), 0.99 % (95 % CI : 0.63,1.47) (n =24/2,431), 1.59 % (95 % CI : 1.02,2.36) (n =24/1,505), and 3.59 % (95 % CI : 2.73,4.63) (n =57/1,588), respectively. The risk score accurately categorizes patients into groups with increasing probabilities of HIV infection. |
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