| Titre : | Helicobacter pylori infection and Hyperemesis gravidarum. An institution-based case-control study. (2008) |
| Auteurs : | Irene SANDVEN ; Michael ABDELNOOR ; Halvard GJONNES ; Kjetil-K MELBY ; Britt-Ingjerd NESHEIM ; Ase VIKANES ; Marianne WETHE ; Centre of Clinical Research. Unit of Epidemiology and Biostatistics. Ulleval University Hospital. Oslo. NOR ; Department of Microbiology. Ulleval University Hospital. Oslo. NOR ; Woman and Child Division. Department of Obstetrics. Ulleval University Hospital. Oslo. NOR |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 23, n° 7, 2008) |
| Pagination : | 491-498 |
| Langues: | Anglais |
| Mots-clés : | Bactériose ; Helicobacter pylori ; Enquête cas témoin ; Epidémiologie ; Ethnie ; Homme ; Infection ; Bactérie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xrEA98. Diffusion soumise à autorisation]. Background : The etiology of Hyperemesis gravidarum (HG) is unclear. To test the hypothesis of an association between Helicobacter pylori infection and HG, an institution-based case-control study was performed at Aker University Hospital (AUH) during 1994-1999. Material and method : From the same source population, 244 incident cases of HG and 244 pregnant women free of the disease (controls) were consecutively identified. Results : H. pylori were noted in 105 cases and 58 control subjects. The presence of H. pylori increased the risk of HG more than two fold (OR=2.42,95% CI : 1.64-3.57, P<0.001). This association was much stronger in Africans as compared to non-Africans (OR=5.26,95% CI : 1.04-26.57 vs. OR=1.67,95% CI : 1.07-2.61) after controlling for the confounding effect of maternal age. A gradient effect of exposure to H. pylori, determined by presence of specific IgG antibody in serum, and increased frequency of HG was present in Africans (test for linear trend P=0.05) and non-Africans (test for linear trend P=0.004). Conclusion : These results indicate that H. pylori increase the risk of HG with a dose-response pattern and stronger in Africans. |
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