Titre :
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Retinoic acid receptor alpha gene variants, multivitamin use, and liver intake as risk factors for oral clefts : A population-based case-control study in Denmark, 1991-1994. (2003)
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Auteurs :
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Laura-E MITCHELL ;
Kaare CHRISTENSEN ;
Jeffrey-C MURRAY ;
Sarah O'BRIEN
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 158, n° 1, 2003)
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Pagination :
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69-76
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Langues:
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Anglais
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Mots-clés :
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Gène
;
Grossesse
;
Foie
;
Facteur risque
;
Enquête cas témoin
;
Danemark
;
Europe
;
Génétique
;
Homme
;
Vitamine
;
Visage
;
Maladie congénitale
;
Malformation
;
Stomatologie
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Résumé :
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[BDSP. Notice produite par INIST-CNRS R0x9J2e6. Diffusion soumise à autorisation]. Previous studies suggest that the risks of non syndromic cleft lip with or without cleft palate (CLIP) and isolated cleft palate are influenced by variation at several loci and that these loci interact with environmental factors to determine disease risk. One putative genetic risk factor for these conditions is the retinoic acid receptor alpha (RARA) locus, which is involved in cell-specific responses to retinoic acid. Hence, RARA may influence disease risk via an interaction with vitamin A and related compounds. Data from a Danish case-control study (1991-1994) were used to evaluate the relations between oral clefts, RARA, and maternal vitamin A exposure from multivitamins and liver. Analyses provided no compelling evidence that the risks of CLIP or isolated cleft palate are related to the RARA variant analyzed. Consistent with several previous studies, the authors'analyses indicated that maternal multivitamin supplement use protects against CLIP. Within the range observed in this population, higher levels of vitamin A intake from multivitamins and liver sources also seemed to protect against CLIP. Exploratory analyses suggested that the latter association was not entirely explained by the association between CLIP and multivitamin use, indicating that adequate levels of vitamin A may be required for normal development of the primary palate.
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