| Titre : | Assessment of risk associated with specific fatty acids and colorectal cancer among French-Canadians in Montreal : a case-control study. Commentary : Cancer. (2003) |
| Auteurs : | André NKONDJOCK ; Parviz GHADIRIAN ; Edward-L GIOVANNUCCI ; Michael-F LEITZMANN ; Patrick MAISONNEUVE ; Bryna SHATENSTEIN ; Département de nutrition. Faculté de médecine. Université de Montréal. Montreal. PQ. CAN ; National Cancer Institute. Nutritional Epidemiology Branch. Rockville. MD. USA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 32, n° 2, 2003) |
| Pagination : | 200-210 |
| Langues: | Anglais |
| Mots-clés : | Facteur risque ; Cancer ; Rectum ; Homme ; Acide gras ; Canada ; Amérique ; Epidémiologie ; Alimentation ; Appareil digestif [pathologie] ; Côlon ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST-CNRS O2NR0xH8. Diffusion soumise à autorisation]. Background : Discrepancies in findings on the association between dietary fats and colorectal cancer (CRC) persist, and it is hypothesized that fatty acids (FA) may modulate CRC risk because of their physiological functions. Methods : Between 1989 and 1993, a case-control study involving 402 cases and 668 population-based controls was conducted among French-Canadians. Dietary intake was assessed by a food frequency questionnaire. Results : Oleic acid was the major FA consumed by the study population. A significant inverse association was found among females between CRC and butyrate (OR=0.57 ; 95% CI : 0.34-0.96 ; P=0.006), alpha-linoleic acid (ALA) (OR=0.78 ; 95% CI : 0.46-1.32 ; P=0.016), and w-3 FA (OR=0.84 ; 95% CI : 0.50-1.41 ; P=0.028), comparing the upper to the lower quartiles of intake. An increased risk was associated with arachidonic acid (AA) (OR=2.03 ; 95% CI : 1.16-3.54 ; P=0.001) among males, and with the w6/w3 ratio (OR=1.47 ; 95% CI : 0.86-2.50 ; P=0.001) among females. Arachidonic acid was linked with up to fivefold increased risk (OR=5.33 ; 95% CI : 2.04-13.95 ; P=0.0004 for trend) among men with high vitamin C intake. Females with low carotenoids intake were at elevated risk associated with AA (OR=4.07 ; 95% CI : 1.84-8.99 ; P=0.003) ; eicosapentaenoic acid (OR=3.50 ; 95% CI : 1.59-7.71 ; P=0.015), and docosahexaenoic acid (OR=5.77 ; 95% CI : 2.50-13.33 ; P=0.002), comparing the upper with the lower quartiles of intake. Conclusion : The results of this study suggest that independently of total energy intake, substituting AA by butyrate, ALA, or oméga-3 FA may reduce CRC risk. The role of interactions between vitamin C, total carotenoids, and polyunsaturated FA requires further investigation. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact