| Titre : | Dietary antioxidants and peripheral arterial disease : The Rotterdam Study. (2001) |
| Auteurs : | Kerstin KLIPSTEIN-GROBUSCH ; Heiner BOEING ; Johanna-H DEN BREEIJEN ; Diederick-E GROBBEE ; Albert HOFMAN ; Jacqueline-Cm WITTEMAN ; Department of Epidemiology and Biostatistics. Erasmus University Medical School. Rotterdam. NLD ; Department of Epidemiology. German Institute of Human Nutrition. Potsdam Rehbrücke. DEU ; Julius Center for Patient Oriented Research. Utrecht University Hospital. Utrecht. NLD |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 154, n° 2, 2001) |
| Pagination : | 145-149 |
| Langues: | Anglais |
| Mots-clés : | Homme ; Sexe ; Epidémiologie ; Europe ; Prévention santé ; Régime alimentaire ; Alimentation ; Questionnaire ; Antioxydant ; Vitamine C ; Vitamine E ; Appareil circulatoire [pathologie] ; Vaisseau sanguin [pathologie] ; Pays Bas |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 5lGBR0xV. Diffusion soumise à autorisation]. This study examined cross-sectionally the association of dietary bêta-carotene, vitamin C, and vitamin E with peripheral arterial disease in Rotterdam, the Netherlands (1990-1993). The 4,367 subjects from the Rotterdam Study were aged 55-94 years and had no previous cardiovascular disease at baseline. Diet was assessed with a food frequency questionnaire. Peripheral arterial disease was defined as an ankle-arm systolic blood pressure index (AAI) of<=0.9 and was present in 204 men and 370 women. In multivariate-adjusted logistic regression analyses, vitamin C intake was significantly inversely associated with peripheral arterial disease in women (highest vs. lowest quartile : relative risk=0.64,95% confidence interval (Cl) : 0.48,0.89 ; ptrend=0.006), and a 100-mg increase in intake was associated with a 0.013 AAI increase (95% Cl : 0.001,0.025). In men, vitamin E intake was inversely associated with peripheral arterial disease (relative risk=0.67,95% Cl : 0.44,1.03 ; ptrend=0.067) ; a 10-mg increase in intake was associated with a 0.015 AAI increase (95% Cl : 0.001,0.031). Whether these differences in antioxidant intake and the risk of a low AAI and of peripheral arterial disease between sexes are attributable to a different food pattern for men compared with women remains to be elucidated. |
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