| Titre : | Dietary fibre and risk of breast cancer in the UK Women's Cohort Study. (2007) |
| Auteurs : | Janet-Elizabeth CADE ; Victoria-Jane BURLEY ; Darren-Charles GREENWOOD ; Uk Women's Cohort Study Steering Group. GBR |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 36, n° 2, 2007) |
| Pagination : | 431-438 |
| Langues: | Anglais |
| Mots-clés : | Fibre alimentaire ; Nutrition ; Régime alimentaire ; Facteur risque ; Adulte ; Cancérologie ; Royaume Uni ; Femme ; Céréale ; Etude prospective ; Homme ; Europe ; Glande mammaire [pathologie] ; Cancer ; Alimentation |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 6EIXVR0x. Diffusion soumise à autorisation]. Background : Reports of relationships between dietary fibre intake and breast cancer have been inconsistent. Previous cohort studies have been limited by a narrow range of intakes. Methods : Women who developed invasive breast cancer, 350 post-menopausally and 257 pre-menopausally, during 240 959 person-years of follow-up in the UK Women's Cohort Study (UKWCS) were studied. This cohort has 35792 subjects with a wide range of exposure to dietary fibre with intakes of total fibre in the lowest quintile of<20g/day up to>30 g/day in the top quintile. Fibre and breast cancer relationships were explored using Cox regression modelling adjusted for measurement error. Effects of fibre, adjusting for confounders were examined for pre-and post-menopausal women separately. Results : In pre-menopausal, but not post-menopausal women a statistically significant inverse relationship was found between total fibre intake and risk of breast cancer (P for trend=0.01). The top quintile of fibre intake was associated with a hazard ratio of 0.48 [95% confidence interval (CI) 0.24-0.96] compared with the lowest quintile. Pre-menopausally, fibre from cereals was inversely associated with risk of breast cancer (P for trend=0.05) and fibre from fruit had a borderline inverse relationship (P for trend=0.09). A further model including dietary folate strengthened the significance of the inverse relationship between total fibre and pre-menopausal breast cancer. Conclusions : These findings suggest that in pre-menopausal women, total fibre is protective against breast cancer ; in particular, fibre from cereals and possibly fruit. |
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