| Titre : | Evidence for an intensity-dependent interaction of NAT2 acetylation genotype and cigarette smoking in the Spanish Bladder Cancer Study. (2007) |
| Auteurs : | Jay-H LUBIN ; Alfredo CARRATO ; Mustafa DOSEMECI ; Montserrat GARCIA-CLOSAS ; Reina GARCIA-CLOSAS ; David-W HEIN ; Manolis KOGEVINAS ; Nuria MALATS ; Nathaniel ROTHMAN ; Consol SERRA ; Debra SILVERMAN ; Adonina TARDON ; Cancer Institute. Division of Cancer Epidemiology and Genetics. Occupational and Environmental Epidemiology Branch. National Rockville. MD. USA ; University of Crete. Medical School. Department of Social Medicine. Heraklion. GRC |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 36, n° 1, 2007) |
| Pagination : | 236-241 |
| Langues: | Anglais |
| Mots-clés : | Facteur risque ; Epidémiologie ; Tabagisme ; Cigarette ; Enquête cas témoin ; Espagne ; Homme ; Cancérologie ; Urologie ; Enzyme ; Europe ; Cancer ; Appareil urinaire [pathologie] ; Génétique ; Néphrologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xaDPj4. Diffusion soumise à autorisation]. Background : The N-acetyltransferase 2 (NAT2) enzyme detoxifies aromatic amines, an important class of carcinogens in tobacco smoke. Slow acetylation phenotype individuals have reduced detoxification capacity compared with those with a rapid/intermediate phenotype. Analysis of the Spanish Bladder Cancer Study found an odds ratio (OR) for slow acetylators relative to rapid/intermediate acetylators of 0.9 in never-smokers and 1.6 in ever-smokers, a 1.8-fold enhancement in smokers. Evidence indicates that acetylation is an exposure-dependent process, and thus the magnitude of the interaction may also depend on exposure level. Methods : We extend a comprehensive three-parameter linear-exponential model for the excess odds ratio (EOR) for smoking to include effects of NAT2 status, and reanalyse smoking and NAT2 status for the bladder cancer data. Results : We show that variations in smoking risk with NAT2 status result from interactions with smoking intensity (cigarettes per day) and not total pack-years of exposure. In addition, the relative increase in smoking risk in NAT2 slo acetylators increases with smoking intensity. Conclusions : Analyses reveal an enhanced effect for smoking intensity and bladder cancer in NAT2 slow acetylators which increases with intensity. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact