| Titre : | Age-specific Differences in Influenza A Epidemic Curves : Do Children Drive the Spread of Influenza Epidemics ? (2011) |
| Auteurs : | Dena SCHANZER ; Louise Pelletier ; Julie VACHON ; Infectious Disease Prevention and Control Branch. Public Health Agency of Canada. Ottawa. ON. CAN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 174, n° 1, 2011) |
| Pagination : | 109-117 |
| Langues: | Anglais |
| Mots-clés : | Infection ; Age ; Etude comparée ; Epidémie ; Epidémiologie ; Enfant ; Interprétation ; Statistique ; Diagnostic ; Procédure ; Pathologie ; Population ; Surveillance ; Virose ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 9H7R0xIp. Diffusion soumise à autorisation]. There is accumulating evidence suggesting that children may drive the spread of influenza epidemics. The objective of this study was to quantify the lead time by age using laboratory-confirmed cases of influenza A for the 1995/1996-2005/2006 seasons from Canadian communities and laboratory-confirmed hospital admissions for the H1 N1/2009 pandemic strain. With alignment of the epidemic curves locally before aggregation of cases, slight age-specific differences in the timing of infection became apparent. For seasonal influenza, both the 10-19-and 20-29-year age groups peaked 1 week earlier than other age groups, while during the fall wave of the 2009 pandemic, infections peaked earlier among only the 10-19-year age group. In the H3N2 seasons, infections occurred an average of 3.9 (95% confidence interval : 1.7,6.1) days earlier in the 20-29-year age group than for youth aged 10-19 years, while during the fall pandemic wave, the 10-19-year age group had a statistically significant lead of 3 days compared with both younger children aged 4-9 years and adults aged 20-29 years (P<0.0001). This analysis casts doubt on the hypothesis that younger school-age children actually lead influenza epidemic waves. |
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