| Titre : | Plasma concentrations of polychlorinated biphenyls and the risk of breast cancer : A congener-specific analysis. (2002) |
| Auteurs : | Alain Demers ; Pierre AYOTTE ; Jacques BRISSON ; Eric Dewailly ; Sylvie DODIN ; Jean Robert ; Département de Médecine Sociale et Préventive. Faculté de Médecine. Université Laval. Ste Foy. CAN ; Unité de Recherche en Santé Publique. Centre de Recherche du Chuq Chul Beauport. PQ. CAN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 155, n° 7, 2002) |
| Pagination : | 629-635 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Sein ; PCB ; Plasma sanguin ; Facteur risque ; Homme ; Femme ; Exposition ; Toxicologie ; Epidémiologie ; Glande mammaire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0x6fgIo. Diffusion soumise à autorisation]. Some reports indicate that exposure to specific polychlorinated biphenyl (PCB) congeners is related to breast cancer risk. The authors recruited participants in a case-control study from October 1994 to March 1997 to assess the relation between breast cancer risk and concentrations of 14 PCB congeners measured in plasma lipids by high-resolution gas chromatography. Participants were incident cases of breast cancer (n=314) and controls (n=523) from the Quebec City region (Canada). Compared with controls, cases had significantly higher concentrations of PCB 99 (p=0.02), PCB 118 (p=0.03), and PCB 156 (p=0.006). Associations were found between breast cancer risk and either PCB 118 (odds ratio (OR)=1.60,95% confidence interval (Cl) : 1.01,2.53 ; fourth vs. first quartile) or PCB 156 (OR=1.80,95% Cl : 1.11,2.94 ; fourth vs. first quartile) concentration. Breast cancer risk was also associated with a total concentration of the three mono-ortho-substituted congeners 105,118, and 156 expressed as 2,3,7,8-tetrachlorodibenzo-p-dioxin toxic equivalents (OR=2.02,95% CI : 1.24,3.28 ; fourth vs. first quartile). These results suggest that exposure to dioxin-like PCBs increases breast cancer risk. Alternatively, the results may be explained by differences between cases and controls regarding metabolic pathways involved in the biotransformation of both mono-ortho PCBs and estrogens. |
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