Résumé :
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[BDSP. Notice produite par INIST-CNRS oR0xSY48. Diffusion soumise à autorisation]. The association of different CD4+cell counts with the same disease risk in treated and untreated populations reflects the effectiveness of highly active antiretroviral therapy (HAART) in persons with human immunodeficiency virus (HIV). Clinical progression of disease following initiation of HAART was determined for 679 HIV-infected men in the Multicenter AIDS Cohort Study by means of Kaplan-Meier survival analyses. Cox proportional hazards models were used to assess the effects of markers of HIV disease, antiretroviral history, and demographic factors. Men who had been followed since January 1993 (pre-HAART) were used to identify CD4+levels associated with the acquired immunodeficiency syndrome (AIDS) - free time equivalent to that of men starting HAART with CD4+cell counts of45 years at initiation (relative hazard=1.92,95% confidence interval : 0.98,3.77). An increase in CD4+cell count of>50 cells/mul immediately after HAART initiation also improved prognosis (relative hazard=0.34,95% confidence interval : 0.16,0.71). AIDS risk in men starting HAART with CD4+counts of
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