| Titre : | Validation of self-reported chronic obstructive pulmonary disease in a cohort study of nurses. (2002) |
| Auteurs : | Rgraham BARR ; Carlos-Ajr CAMARGO ; Julie HERBSTMAN ; Frank-E SPEIZER ; General Medicine Division. Department of Medicine. Massachusetts General Hospital. Harvard Medical School. Boston. MA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 155, n° 10, 2002) |
| Pagination : | 965-971 |
| Langues: | Anglais |
| Mots-clés : | Bronchopneumopathie obstructive ; Questionnaire ; Homme ; Infirmier ; Epidémiologie ; Validation ; Dossier médical ; Appareil respiratoire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS OpLR0xEP. Diffusion soumise à autorisation]. Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death, and its prevalence is increasing ; however, few strategies are available for disease prevention or modification besides smoking interventions, To facilitate examination of modifiable risk factors for COPD in the Nurses'Health Study, the authors validated a questionnaire-based definition of COPD in a subset of this US cohort. Participants were surveyed biennially about lifestyle factors, including smoking, since 1976 and physician diagnosis of COPD since 1988. Self-reported cases were defined as reporting COPD on both the original (1988-1996) and supplemental (1998) questionnaires. The authors requested medical records for a 10% random sample of 2,790 cases and reviewed these records in a systematic, blinded fashion. Validated cases required obstructive spirometry, emphysema on chest radiograph or computed tomography, or physician diagnosis. COPD was confirmed for 78% of 273 cases. Spirometry or radiographic results were available for 84% ; when available, mean forced expiratory volume in 1 second was 51% predicted (standard deviation, 19). Applying these results to a hypothetical cohort, the authors estimated the degree to which disease misclassification biases relative risks toward the null value, confirming that questionnaire-based COPD research should focus on minimizing false positives rather than false negatives. In conclusion, COPD can be studied in large, questionnaire-based cohorts of health professionals. |
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