| Titre : | Opportunity for catch-up HPV vaccination in young women after first delivery. (2010) |
| Auteurs : | RAMA (Cristina-Helena) : BRA. Hospital Maternidade Leonor Mendes de Barros. Sao Paulo. ; Venancio-Af ALVES ; Maria-A ANDREOLI ; Maria-C COSTA ; Jose ELUF-NETO ; LONGATTO (Adhemar) : PRT. Life and Health Sciences Research Institute (Icvs). School of Health Sciences. University of Minho. Braga. ; PAGLIUSI (Sonia) : CHE. Ludwig Institute for Cancer Research. Lausanne. ; THOMANN (Patricia) : BRA. Qiagen do Brasil. Sao Paulo. ; Luisa-L VILLA ; Ludwig Institute for Cancer Research. Sao Paulo. BRA ; University of Sao Paulo School of Medicine. Sao Paulo. BRA |
| Type de document : | Article |
| Dans : | Journal of epidemiology and community health (vol. 64, n° 7, 2010) |
| Pagination : | 610-615 |
| Langues: | Anglais |
| Mots-clés : | Prévention santé ; Infection ; Vaccination ; Jeune adulte ; Femme ; Facteur risque ; Accouchement ; Brésil ; Epidémiologie ; Prévalence ; Vaccin ; Virus ; Homme ; Amérique ; Amérique du Sud |
| Résumé : | [BDSP. Notice produite par INIST-CNRS jssoDR0x. Diffusion soumise à autorisation]. Background. Early age at first delivery has been identified as a risk factor for high-risk HPV-type infection and cervical cancer development. Methods. A cross-sectional study was carried out in a large public maternity hospital in Sao Paulo, Brazil. During June 2006 to February 2007,301 women aged 15-24 years who gave birth to their first child were recruited between 43 and 60 days after delivery. Detection of HPV DNA in cervical specimens was performed using a standardised PCR protocol with PGMY09/11 primers. The association of selected factors with HPV infection was assessed by using a Generalised Linear Model. Results. HPV DNA was detected in 58.5% (95% CI 52.7% to 64.0%) of the enrolled young women. The most common types of HPV found were : HPV16, HPV51, HPV52, HPV58 and HPV71. The overall prevalence of HPV types targeted by the HPV prophylactic vaccines was : HPV 16-12.0%, HPV 18-2.3% and HPV 6 and 11 4.3%. In the multivariate analysis, only age (inversely, p for trend=0.02) and smoking habits were independently associated with HPV infection. Conclusions. The findings show that these young primiparous women had high cervical HPV prevalence, suggesting that this is a high-risk group for cervical cancer development. Nevertheless, 17.3% were positive for any of the four HPV types included in HPV vaccines (HPV6,11,16 or 18), with 13.3% positive for HPV 16 or 18 and only 1.0% having both vaccine related-oncogenic HPV types. Thus, young primiparous women could benefit from catch-up HPV vaccination programmes. |
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