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Age at natural menopause and total mortality and mortality from ischemic heart disease : The Adventist health study.

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Titre :	Age at natural menopause and total mortality and mortality from ischemic heart disease : The Adventist health study. (1999)
Auteurs :	B.K. JACOBSEN ; G.E. FRASER ; S.F. KNUTSEN ; Center for Health Research and Department of Epidemiology and Biostatistics. School of Public Health. Loma Linda University. Loma Linda. CA. USA
Type de document :	Article
Dans :	Journal of clinical epidemiology (vol. 52, n° 4, 1999)
Pagination :	303-307
Langues:	Anglais
Mots-clés :	Mortalité ; Ménopause ; Age ; Infarctus ; Myocarde ; Epidémiologie ; Facteur risque ; Homme ; Appareil circulatoire [pathologie] ; Cardiopathie coronaire ; Myocarde [pathologie]
Résumé :	[BDSP. Notice produite par INIST R0xwb47M. Diffusion soumise à autorisation]. We studied the relationship between age at natural menopause and total mortality as well as mortality from ischemic heart disease in a cohort of 6182 California Seventh-Day Adventist women who reported a natural menopause. During follow-up from 1976 through 1988, there were 1831 deaths. A total of 308 deaths due to ischemic heart disease occurred in women who denied ischemic heart disease at start of follow-up. An early menopause was associated with increased total mortality (P value for linear trend<0.001) and ischemic heart disease mortality (P value for linear trend=0.03). This relationship could not be explained by possible confounding variables. Our results support the hypothesis that an early natural menopause (35-40 years old) increases the risk of ischemic heart disease. There is, however, also some evidence of increased risk of ischemic heart disease in women with a very late menopause (>55 years), particularly in women who never have used postmenopausal estrogens.